The spindle checkpoint, aneuploidy, and cancer (Q33976673)

30 July 2017

1 reference

title

The spindle checkpoint, aneuploidy, and cancer (English)

1 reference

30 July 2017

Rajnish Bharadwaj

1

1 reference

30 July 2017

Hongtao Yu

series ordinal

2

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 March 2004

1 reference

30 July 2017

1 reference

30 July 2017

23

1 reference

30 July 2017

2016-2027

1 reference

30 July 2017

11

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207374

30 July 2017

0 references

cites work

CENP-E as an essential component of the mitotic checkpoint in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The Ran GTPase regulates kinetochore function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mutations of mitotic checkpoint genes in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Control of mitotic transitions by the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Identification of a MAD2-binding protein, CMT2, and its role in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The anaphase-promoting complex: it's not just for mitosis any more.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

A new view of the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Budding yeast Cdc20: a target of the spindle checkpoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Chromosome segregation and cancer: cutting through the mystery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Yeast Dam1p is required to maintain spindle integrity during mitosis and interacts with the Mps1p kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Feedback control of mitosis in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The mitotic spindle is required for loading of the DASH complex onto the kinetochore

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Identification of a human mitotic checkpoint gene: hsMAD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The spindle checkpoint: structural insights into dynamic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Segregating sister genomes: the molecular biology of chromosome separation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Splitting the chromosome: cutting the ties that bind sister chromatids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The anaphase-promoting complex: proteolysis in mitosis and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Phosphorylation of human MAD1 by the BUB1 kinase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Bi-orienting chromosomes on the mitotic spindle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Distinct chromosome segregation roles for spindle checkpoint proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mad2 transiently associates with an APC/p55Cdc complex during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mitotic checkpoints: from yeast to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mad2 phosphorylation regulates its association with Mad1 and the APC/C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Centrosomes and checkpoints: the MPS1 family of kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Kinetochore dynein: its dynamics and role in the transport of the Rough deal checkpoint protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Regulation of APC-Cdc20 by the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Identification of a cullin homology region in a subunit of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

The maize homologue of the cell cycle checkpoint protein MAD2 reveals kinetochore substructure and contrasting mitotic and meiotic localization patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

7 January 2021

Association of human SCF(SKP2) subunit p19(SKP1) with interphase centrosomes and mitotic spindle poles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

7 January 2021

hBUB1 defects in leukemia and lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207374

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207374

1 reference

Dimensions Publication ID

30 July 2017

1040628523

0 references

Fatcat ID

release_lcy2bis3urdmhh3cgnb6p4ycl4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lcy2bis3urdmhh3cgnb6p4ycl4

24 November 2022

mapped directly with Wikidata item

1 reference