Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation. (Q33978723)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25132836%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation (English)

1 reference

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12 March 2020

0 references

4

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12 March 2020

author name string

James Q Wang

series ordinal

1

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12 March 2020

Yogesh S Jeelall

series ordinal

2

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12 March 2020

Laura L Ferguson

series ordinal

3

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12 March 2020

publication date

31 July 2014

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12 March 2020

published in

Frontiers in Immunology

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12 March 2020

volume

5

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12 March 2020

page(s)

367

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Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance

12 March 2020

cites work

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Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells.

5 July 2018

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A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease

5 July 2018

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5 July 2018

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

5 July 2018

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5 July 2018

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Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells

5 July 2018

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5 July 2018

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5 July 2018

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STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

5 July 2018

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Localisation and trafficking of Toll-like receptors: an important mode of regulation.

5 July 2018

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

5 July 2018

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

5 July 2018

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STATs in cancer inflammation and immunity: a leading role for STAT3

5 July 2018

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A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

5 July 2018

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Direct activation of protein kinases by unanchored polyubiquitin chains

5 July 2018

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Redefining chronic viral infection

5 July 2018

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MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

5 July 2018

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AP-1 activated by toll-like receptors regulates expression of IL-23 p19.

5 July 2018

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Eradication therapy for Helicobacter pylori in patients with gastric MALT lymphoma: a pooled data analysis

5 July 2018

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Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

5 July 2018

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5 July 2018

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STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK/T-cell lymphoma

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Origin and physiological roles of inflammation

5 July 2018

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The IkappaB kinase complex: master regulator of NF-kappaB signaling

5 July 2018

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Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells

5 July 2018

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5 July 2018

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

5 July 2018

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Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Nuclear factor-kappaB in cancer development and progression

5 July 2018

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

5 July 2018

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Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

5 July 2018

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5 July 2018

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5 July 2018

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

5 July 2018

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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

5 July 2018

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The role of IL-6 and STAT3 in inflammation and cancer

5 July 2018

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5 July 2018

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Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).

5 July 2018

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

5 July 2018

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Chronic lymphocytic leukemia

5 July 2018

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

5 July 2018

1 reference

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Leaky catecholamine stores: undue waste or a stress response coping mechanism?

5 July 2018

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Toll-like receptor signalling

5 July 2018

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Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

5 July 2018

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5 July 2018

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5 July 2018

TLR signaling pathways

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TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

5 July 2018

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A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

5 July 2018

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Regulated portals of entry into the cell

5 July 2018

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5 July 2018

1 reference

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5 July 2018

Inflammation and cancer

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

5 July 2018

1 reference

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IRF3 mediates a TLR3/TLR4-specific antiviral gene program

5 July 2018

1 reference

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Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

5 July 2018

1 reference

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Distinct molecular mechanism for initiating TRAF6 signalling

5 July 2018

1 reference

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Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness

5 July 2018

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Innate immune recognition

5 July 2018

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Type I Helicobacter pylori lipopolysaccharide stimulates toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells

5 July 2018

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Mouse plasmacytoma: an experimental model of human multiple myeloma.

5 July 2018

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Role of activated host T cells in the promotion of MALT lymphoma growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Infections as a major preventable cause of human cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Structure of an IkappaBalpha/NF-kappaB complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

MyD88, an adapter protein involved in interleukin-1 signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Approaching the asymptote? Evolution and revolution in immunology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Drosophila Toll and IL-1 receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

5 July 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

Two levels of protection for the B cell genome during somatic hypermutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

29 October 2018

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2014.00367

An Address on the Value of Pathological Experiments

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4116802

Prognostic value of plasma interleukin-6 levels in patients with chronic lymphocytic leukemia

29 October 2018

1 reference

12 December 2020

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B

1 reference

12 December 2020

Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori

1 reference

12 December 2020

Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma

1 reference

12 December 2020

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

1 reference

12 December 2020

Mammalian Toll-like receptors

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2014.00367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25132836%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25132836%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

25132836

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25132836%20AND%20SRC:MED&resulttype=core&format=json