ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. (Q33980322)

30 July 2017

title

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. (English)

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amyotrophic lateral sclerosis

30 July 2017

main subject

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5

Robert H Brown

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30 July 2017

Steve Pedrini

1

1 reference

30 July 2017

Daniela Sau

2

1 reference

30 July 2017

Stefania Guareschi

3

1 reference

30 July 2017

Marina Bogush

4

1 reference

30 July 2017

Nicole Naniche

6

1 reference

30 July 2017

Azadeh Kia

7

1 reference

30 July 2017

Davide Trotti

8

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30 July 2017

Piera Pasinelli

9

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30 July 2017

publication date

11 May 2010

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30 July 2017

published in

Human Molecular Genetics

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30 July 2017

volume

19

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30 July 2017

issue

15

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30 July 2017

page(s)

2974-2986

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Mitochondrial membrane permeabilization in neuronal injury

30 July 2017

cites work

1 reference

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

28 July 2018

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28 July 2018

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28 July 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

28 July 2018

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ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

28 July 2018

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Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

28 July 2018

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Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

28 July 2018

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Conversion of Bcl-2 to a Bax-like death effector by caspases

28 July 2018

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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

28 July 2018

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28 July 2018

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28 July 2018

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

28 July 2018

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Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

28 July 2018

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

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A quantitative histochemical assay for activities of mitochondrial electron transport chain complexes in mouse spinal cord sections.

21 January 2018

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Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

21 January 2018

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Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice.

21 January 2018

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Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

21 January 2018

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An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis

21 January 2018

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Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.

21 January 2018

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Mitochondrial membrane permeabilization in cell death

21 January 2018

1 reference

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The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals.

21 January 2018

1 reference

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Structure—Function Analysis of Bcl-2 Family Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ202

Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

21 January 2018

1 reference

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Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

12 December 2020

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

1 reference

12 December 2020

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS

1 reference

12 December 2020

Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDQ202

1 reference

30 July 2017

1 reference

30 July 2017

1 reference