The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation (Q33985893)

30 July 2017

title

The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation (English)

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30 July 2017

Zhenbao Yu

1

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30 July 2017

Gillian Vogel

2

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30 July 2017

Yan Coulombe

3

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30 July 2017

Danielle Dubeau

4

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30 July 2017

Elizabeth Spehalski

5

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30 July 2017

Josée Hébert

6

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30 July 2017

David O Ferguson

7

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30 July 2017

Jean Yves Masson

8

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30 July 2017

Stéphane Richard

9

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30 July 2017

publication date

9 August 2011

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30 July 2017

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30 July 2017

volume

22

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30 July 2017

issue

2

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30 July 2017

page(s)

305-320

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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

30 July 2017

cites work

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Multiple functions of MRN in end-joining pathways during isotype class switching

28 July 2018

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Role of mammalian Mre11 in classical and alternative nonhomologous end joining

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

28 July 2018

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DNA end resection: many nucleases make light work

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Arginine methylation an emerging regulator of protein function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

ATR couples FANCD2 monoubiquitination to the DNA-damage response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

DNA damage-dependent nuclear dynamics of the Mre11 complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

The DNA damage response: putting checkpoints in perspective

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Rapid destruction of human Cdc25A in response to DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

Protein arginine methylation in mammals: who, what, and why

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Protein interfaces in signaling regulated by arginine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Human CtIP promotes DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Multiple roles for MRE11 at uncapped telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

A glycine-arginine domain in control of the human MRE11 DNA repair protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2011.128

DNA replication-dependent nuclear dynamics of the Mre11 complex.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271587

29 October 2018

Identifiers

DOI

10.1038/CR.2011.128

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30 July 2017

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30 July 2017

1 reference