Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells (Q39820516)

14 September 2017

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells (English)

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14 September 2017

Emilie Rass

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14 September 2017

Anastazja Grabarz

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14 September 2017

Isabelle Plo

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14 September 2017

Jean Gautier

4

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14 September 2017

Pascale Bertrand

5

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14 September 2017

Bernard S Lopez

6

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14 September 2017

26 July 2009

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Nature Structural & Molecular Biology

14 September 2017

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14 September 2017

16

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14 September 2017

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14 September 2017

819-824

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https://scigraph.springernature.com/pub.10.1038/nsmb.1641

14 September 2017

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cites work

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

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An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

31 March 2020

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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

31 March 2020

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Gene conversion: mechanisms, evolution and human disease

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Recombination hot spots and human disease

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Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

31 March 2020

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Rescue of arrested replication forks by homologous recombination

31 March 2020

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

31 March 2020

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Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

31 March 2020

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Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

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Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.

31 March 2020

1 reference

Rag mutations reveal robust alternative end joining

31 March 2020

2 references

https://pubmed.ncbi.nlm.nih.gov/19633668

31 March 2020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

1 reference

MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings

31 March 2020

1 reference

Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.

31 March 2020

1 reference

Biochemical evidence for Ku-independent backup pathways of NHEJ

31 March 2020

1 reference

IgH class switching and translocations use a robust non-classical end-joining pathway

31 March 2020

1 reference

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

31 March 2020

1 reference

Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.

31 March 2020

1 reference

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

31 March 2020

1 reference

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

31 March 2020

1 reference

The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae

31 March 2020

1 reference

Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences

31 March 2020

1 reference

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

31 March 2020

1 reference

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

31 March 2020

1 reference

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

31 March 2020

1 reference

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.

31 March 2020

1 reference

Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction

31 March 2020

1 reference

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

31 March 2020

1 reference

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

31 March 2020

1 reference

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

31 March 2020

1 reference

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

31 March 2020

1 reference

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

31 March 2020

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

31 March 2020

1 reference

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

31 March 2020

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Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

31 March 2020

1 reference

Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining

31 March 2020

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Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

31 March 2020

1 reference

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

31 March 2020

1 reference

Human CtIP promotes DNA end resection

31 March 2020

1 reference

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

31 March 2020

1 reference

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

31 March 2020

1 reference

A novel recombination pathway initiated by the Mre11/Rad50/Nbs1 complex eliminates palindromes during meiosis in Schizosaccharomyces pombe

31 March 2020

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Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

31 March 2020

1 reference

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

31 March 2020

1 reference

Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions

31 March 2020

1 reference

Multiple functions of MRN in end-joining pathways during isotype class switching

31 March 2020

1 reference

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

31 March 2020

1 reference

PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

31 March 2020

1 reference

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

31 March 2020

1 reference

CDK targets Sae2 to control DNA-end resection and homologous recombination

31 March 2020

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Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

31 March 2020

1 reference

XRCC4 in G1 suppresses homologous recombination in S/G2, in G1 checkpoint-defective cells

31 March 2020

1 reference

Direct DNA binding by Brca1

31 March 2020

1 reference

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.

31 March 2020

1 reference

S-phase progression stimulates both the mutagenic KU-independent pathway and mutagenic processing of KU-dependent intermediates, for nonhomologous end joining

31 March 2020

1 reference

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

31 March 2020

1 reference

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

31 March 2020

1 reference

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19633668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple roles for MRE11 at uncapped telomeres

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19633668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1641

1 reference

14 September 2017

1 reference