Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. (Q33986353)

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9 February 2020

title

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling (English)

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9 February 2020

author name string

Wenjing Guo

1

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9 February 2020

Jing Zhang

3

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Wei Zhang

4

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Alastair Morrison

5

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Philip Hayes

6

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Steve Wilson

7

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Tongsheng Chen

8

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Jie Zhao

9

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publication date

8 August 2011

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Journal of Neuroscience Research

9 February 2020

published in

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volume

89

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issue

11

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page(s)

1723-1736

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

9 February 2020

cites work

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SIRT1 regulates circadian clock gene expression through PER2 deacetylation

21 January 2018

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Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

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Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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Overexpression of growth-associated proteins in the neurons of adult transgenic mice

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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

21 January 2018

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

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Resveratrol stimulates AMP kinase activity in neurons

21 January 2018

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

21 January 2018

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Functions and regulation of the 70kDa ribosomal S6 kinases.

21 January 2018

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

21 January 2018

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A novel pathway regulates memory and plasticity via SIRT1 and miR-134

21 January 2018

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SIRT1 negatively regulates the mammalian target of rapamycin

21 January 2018

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Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

21 January 2018

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Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons

21 January 2018

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Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

21 January 2018

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Caloric restriction in humans

21 January 2018

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SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts

21 January 2018

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.

21 January 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

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Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.

21 January 2018

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

21 January 2018

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a

21 January 2018

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

21 January 2018

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Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

21 January 2018

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The critical role of the class III histone deacetylase SIRT1 in cancer

21 January 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

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Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin

21 January 2018

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Sirtuins in mammals: insights into their biological function

21 January 2018

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SIRT1 is essential for normal cognitive function and synaptic plasticity

21 January 2018

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Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

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SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity

21 January 2018

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Modulation of SIRT1 expression in different neurodegenerative models and human pathologies

21 January 2018

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

21 January 2018

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Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity

21 January 2018

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

21 January 2018

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Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

21 January 2018

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 January 2018

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SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

21 January 2018

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Resveratrol and ischemic preconditioning in the brain

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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SKAR is a specific target of S6 kinase 1 in cell growth control

21 January 2018

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Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

21 January 2018

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Regulation of protein turnover by acetyltransferases and deacetylases.

21 January 2018

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SIRT1 activation confers neuroprotection in experimental optic neuritis

21 January 2018

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In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

21 January 2018

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Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells

21 January 2018

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SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox

21 January 2018

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Sirt1's complex roles in neuroprotection

21 January 2018

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

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Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1.

21 January 2018

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PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons

21 January 2018

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.22725

1 reference

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9 February 2020

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