PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway (Q33994685)

30 July 2017

title

PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway (English)

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30 July 2017

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Chun-Yan Wu

1

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30 July 2017

Zhi-Han Tang

2

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30 July 2017

Lu Jiang

3

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30 July 2017

Xue-Fei Li

4

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30 July 2017

Zhi-Sheng Jiang

5

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30 July 2017

Lu-Shan Liu

6

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30 July 2017

publication date

17 August 2011

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Molecular and Cellular Biochemistry

30 July 2017

published in

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30 July 2017

volume

359

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30 July 2017

issue

1-2

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30 July 2017

page(s)

347-358

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Molecular biology of PCSK9: its role in LDL metabolism

30 July 2017

cites work

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A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke

21 January 2018

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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 January 2018

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Endothelial cell apoptosis in angiogenesis and vessel regression

21 January 2018

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Role of reactive oxygen species and Bax in oxidized low density lipoprotein-induced apoptosis of human monocytes.

21 January 2018

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The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA).

21 January 2018

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Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols

21 January 2018

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Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells

21 January 2018

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Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture.

21 January 2018

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Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase

21 January 2018

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Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet

21 January 2018

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Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

21 January 2018

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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

21 January 2018

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Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway.

21 January 2018

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

21 January 2018

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

21 January 2018

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Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

21 January 2018

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Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells

21 January 2018

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12 December 2020

Targeting PCSK9 for the treatment of hypercholesterolemia.

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12 December 2020

Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells

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12 December 2020

Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction

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12 December 2020

LOX-1 and atherosclerosis: proof of concept in LOX-1-knockout mice

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12 December 2020

10.1007/S11010-011-1028-6

Identifiers

DOI

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Dimensions Publication ID

30 July 2017

1029052853

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