Drug delivery across the blood-brain barrier: why is it difficult? how to measure and improve it? (Q33995372)

30 July 2017

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title

Drug delivery across the blood-brain barrier: why is it difficult? how to measure and improve it? (English)

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30 July 2017

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Yaming Su

1

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30 July 2017

Patrick J Sinko

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

1 May 2006

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Expert Opinion on Drug Delivery

30 July 2017

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30 July 2017

3

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30 July 2017

3

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30 July 2017

419-435

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Fine structural localization of a blood-brain barrier to exogenous peroxidase

30 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte loss

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Endothelial-pericyte interactions in angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Role of the CNS microvascular pericyte in the blood-brain barrier

21 January 2018

1 reference

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Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Glial cells and neurons induce blood-brain barrier related enzymes in cultured cerebral endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice

21 January 2018

1 reference

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A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

21 January 2018

1 reference

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Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

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Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Prediction of intestinal absorption and blood-brain barrier penetration by computational methods

21 January 2018

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Blood-brain barrier permeation: molecular parameters governing passive diffusion

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Designing libraries with CNS activity

21 January 2018

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Blood-brain barrier permeation models: discriminating between potential CNS and non-CNS drugs including P-glycoprotein substrates

21 January 2018

1 reference

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Symmetry and structure in P-glycoprotein and ABC transporters what goes around comes around

21 January 2018

1 reference

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

1 reference

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Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.

21 January 2018

1 reference

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.3.3.419

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Expression of P-glycoprotein in human cerebral cortex microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

21 January 2018

1 reference

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A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

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ABC transporters as phenotypic markers and functional regulators of stem cells

21 January 2018

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Active efflux across the blood-brain barrier: role of the solute carrier family

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

21 January 2018

1 reference

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Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells

21 January 2018

1 reference

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Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)

21 January 2018

1 reference

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Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

21 January 2018

1 reference

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Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier

21 January 2018

1 reference

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Vascular proteomics and subtractive antibody expression cloning

21 January 2018

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How to measure drug transport across the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517%2F17425247.3.3.419

SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.

21 January 2018

1 reference

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F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors

21 January 2018

1 reference

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Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

21 January 2018

1 reference

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Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

A cell culture model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Astroglial cells inhibit the increasing permeability of brain endothelial cell monolayer following hypoxia/reoxygenation.

21 January 2018

1 reference

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An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells

21 January 2018

1 reference

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Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Predicting blood-brain barrier permeability of drugs: evaluation of different in vitro assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Transferrin receptor polarity and recycling accuracy in "tight" and "leaky" strains of Madin-Darby canine kidney cells

21 January 2018

1 reference

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Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells

21 January 2018

1 reference

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Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

21 January 2018

1 reference

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

1 reference

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Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Electrical resistance of brain microvascular endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Effect of histamine and antagonists on electrical resistance across the blood-brain barrier in rat brain-surface microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice

21 January 2018

1 reference

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Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier

21 January 2018

1 reference

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Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

A critical evaluation of the brain efflux index method as applied to the nitric oxide synthase inhibitor, aminoguanidine

21 January 2018

1 reference

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Increased delivery of tumor-specific monoclonal antibodies to brain after osmotic blood-brain barrier modification in patients with melanoma metastatic to the central nervous system.

21 January 2018

1 reference

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Transport of molecules from nose to brain: transneuronal anterograde and retrograde labeling in the rat olfactory system by wheat germ agglutinin-horseradish peroxidase applied to the nasal epithelium.

21 January 2018

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Receptor-mediated peptide transport through the blood-brain barrier

21 January 2018

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Drug transport to brain with targeted nanoparticles

21 January 2018

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ABC transporters and the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425247.3.3.419

Drugs as P-glycoprotein substrates, inhibitors, and inducers

21 January 2018

1 reference

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Effect of P-glycoprotein modulators on the pharmacokinetics of camptothecin using microdialysis

21 January 2018

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Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein

21 January 2018

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The acridonecarboxamide GF120918 potently reverses P-glycoprotein-mediated resistance in human sarcoma MES-Dx5 cells

21 January 2018

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Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

21 January 2018

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Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor.

21 January 2018

1 reference

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Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein

21 January 2018

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A phase I and pharmacologic study of idarubicin, cytarabine, etoposide, and the multidrug resistance protein (MDR1/Pgp) inhibitor PSC-833 in patients with refractory leukemia

21 January 2018

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Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)

21 January 2018

1 reference

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Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

21 January 2018

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A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors

21 January 2018

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Mechanisms of glucose transport at the blood-brain barrier: an in vitro study

21 January 2018

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The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

21 January 2018

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Selective expression of the large neutral amino acid transporter at the blood-brain barrier

21 January 2018

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Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique

21 January 2018

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Human blood-brain barrier insulin receptor

21 January 2018

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Human blood-brain barrier transferrin receptor

21 January 2018

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Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels

21 January 2018

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Brain drug delivery of small molecules using immunoliposomes

21 January 2018

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Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy

21 January 2018

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Drug and gene targeting to the brain with molecular Trojan horses

21 January 2018

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Nanoparticulate systems for brain delivery of drugs

21 January 2018

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Synthesis of pegylated immunonanoparticles

21 January 2018

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Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor

21 January 2018

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Delivery of bioactive molecules into the cell: the Trojan horse approach

21 January 2018

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Quantitative assessment of the cell penetrating properties of RI-Tat-9: evidence for a cell type-specific barrier at the plasma membrane of epithelial cells

21 January 2018

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Doxorubicin-peptide conjugates overcome multidrug resistance

21 January 2018

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Intravenous TAT-GDNF is protective after focal cerebral ischemia in mice

21 January 2018

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In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

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Drug targeting. Breaking down barriers.

21 January 2018

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Astrocytes induce blood–brain barrier properties in endothelial cells

21 January 2018

1 reference

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Assessing the efficacy of highly active antiretroviral therapy in the brain.

21 January 2018

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Predicting blood-brain transport of drugs: a computational approach

21 January 2018

1 reference

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Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

21 January 2018

1 reference

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Glucose transporter localization in brain using light and electron immunocytochemistry

21 January 2018

1 reference

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Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies

21 January 2018

1 reference

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Astrocytic contributions to blood-brain barrier (BBB) formation by endothelial cells: a possible use of aortic endothelial cell for in vitro BBB model

21 January 2018

1 reference

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Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

21 January 2018

1 reference

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Distribution of nerve growth factor following direct delivery to brain interstitium

21 January 2018

1 reference

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The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

21 January 2018

1 reference

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Receptor-mediated transport of insulin across endothelial cells

21 January 2018

1 reference

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Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1517/17425247.3.3.419

1 reference

release_qa63c4rfmrh25d2cgendsdslta

30 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qa63c4rfmrh25d2cgendsdslta

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference