LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis (Q33998653)

30 July 2017

1 reference

title

LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis (English)

1 reference

30 July 2017

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4

Masliah E

1 reference

30 July 2017

Van Uden E

1

1 reference

PubMed ID

10936878

30 July 2017

Kang DE

series ordinal

2

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PubMed ID

10936878

30 July 2017

Koo EH

series ordinal

3

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30 July 2017

1 August 2000

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Microscopy Research and Technique

30 July 2017

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30 July 2017

50

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30 July 2017

4

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30 July 2017

268-272

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The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

30 July 2017

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

21 January 2018

1 reference

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Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia.

21 January 2018

1 reference

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Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Mutation analysis of presenillin 1 gene in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Intracellular signaling from the endoplasmic reticulum to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Reelin is a ligand for lipoprotein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Expression and distribution of low density lipoprotein receptor-related protein mRNA in the rat central nervous system.

21 January 2018

1 reference

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Increased A beta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Association of human, rat, and rabbit apolipoprotein E with beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein li

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

The apolipoprotein epsilon 4 allele in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Cerebrospinal fluid apolipoprotein E level is increased in late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Direct association of presenilin-1 with beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Apolipoprotein E polymorphism and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Splicing together the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Presenilins and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): is LRP central to Alzheimer's disease pathogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Genetic studies on chromosome 12 in late-onset Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0029%2820000815%2950%3A4%3C268%3A%3AAID-JEMT3%3E3.0.CO%3B2-1

10.1002/1097-0029(20000815)50:4<268::AID-JEMT3>3.0.CO;2-1

21 January 2018

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10936878