Pluronics and MDR reversal: an update. (Q34005678)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

2 references

26 October 2020

8 February 2021

Pluronics and MDR reversal: an update (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

3 April 2019

physiological phenomenon

1 reference

20 August 2019

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1 October 2019

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7 November 2019

macromolecular substance

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antineoplastic resistance

16 November 2019

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26 October 2020

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8 February 2021

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

author name string

Daria Y Alakhova

series ordinal

1

1 reference

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language of work or name

English

0 references

publication date

10 July 2014

1 reference

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21 March 2020

4 August 2014

2 references

26 October 2020

8 February 2021

Molecular Pharmaceutics

8 references

3 April 2019

20 August 2019

1 October 2019

7 November 2019

16 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

26 October 2020

8 February 2021

11

1 reference

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21 March 2020

issue

8

1 reference

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21 March 2020

page(s)

2566-2578

1 reference

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Multidrug resistance: Physiological principles and nanomedical solutions.

21 March 2020

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Reversing multidrug resistance by intracellular delivery of Pluronic® P85 unimers

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Effect of doxorubicin/pluronic SP1049C on tumorigenicity, aggressiveness, DNA methylation and stem cell markers in murine leukemia

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Propofol inhibits invasion and enhances paclitaxel- induced apoptosis in ovarian cancer cells through the suppression of the transcription factor slug

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Cytocompatibility and P-glycoprotein inhibition of block copolymers: structure-activity relationship.

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Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation

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A simple way to enhance Doxil® therapy: drug release from liposomes at the tumor site by amphiphilic block copolymer.

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Poly(styrene oxide)-poly(ethylene oxide) block copolymers: From "classical" chemotherapeutic nanocarriers to active cell-response inducers.

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Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: optimization and in vitro, in vivo evaluation.

5 July 2018

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Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer

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Nature of interactions between PEO-PPO-PEO triblock copolymers and lipid membranes: (II) role of hydration dynamics revealed by dynamic nuclear polarization

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Cancer stem cells: current status and evolving complexities

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Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs

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Nanotechnology applied to overcome tumor drug resistance

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Chitosan-Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study

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Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes

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Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors.

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Cancer stem cells: impact, heterogeneity, and uncertainty

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MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression

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Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake

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Role of Pluronic block copolymers in modulation of heat shock protein 70 expression

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Structural parameters governing activity of Pluronic triblock copolymers in hyperthermia cancer therapy

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Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

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Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.

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Effects of PEO-PPO-PEO triblock copolymers on phospholipid membrane integrity under osmotic stress

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

5 July 2018

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A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

5 July 2018

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Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers.

5 July 2018

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The utilization of pathogen-like cellular trafficking by single chain block copolymer

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Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers.

5 July 2018

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5 July 2018

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5 July 2018

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

5 July 2018

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How epigenetics can explain human metastasis: a new role for microRNAs

5 July 2018

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Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer

5 July 2018

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Prevention of MDR development in leukemia cells by micelle-forming polymeric surfactant

5 July 2018

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Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells

5 July 2018

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Glutathione and apoptosis

5 July 2018

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Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers

5 July 2018

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Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice

5 July 2018

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5 July 2018

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ABC multidrug transporters: structure, function and role in chemoresistance.

5 July 2018

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Effect of excipients on breast cancer resistance protein substrate uptake activity

5 July 2018

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Natural and synthetic polymers as inhibitors of drug efflux pumps

5 July 2018

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Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia

5 July 2018

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ABCG2: determining its relevance in clinical drug resistance

5 July 2018

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Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines

5 July 2018

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Cholesterol: Coupling between membrane microenvironment and ABC transporter activity

5 July 2018

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Dynamics in the plasma membrane: how to combine fluidity and order.

5 July 2018

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Alteration of genomic responses to doxorubicin and prevention of MDR in breast cancer cells by a polymer excipient: pluronic P85.

5 July 2018

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Differentiation-related changes in mitochondrial properties as indicators of stem cell competence

5 July 2018

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Quantification and characterization of P-glycoprotein-substrate interactions

5 July 2018

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Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells.

5 July 2018

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Interaction between lipid monolayers and poloxamer 188: an X-ray reflectivity and diffraction study

5 July 2018

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Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells

5 July 2018

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Multidrug-resistant cancer cells contain two populations of P-glycoprotein with differently stimulated P-gp ATPase activities: evidence from atomic force microscopy and biochemical analysis

5 July 2018

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Effect of pluronic P85 on ATPase activity of drug efflux transporters

5 July 2018

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Cancer multidrug resistance: a review of recent drug discovery research.

5 July 2018

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Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

5 July 2018

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Overexpression of caveolin-1 increases plasma membrane fluidity and reduces P-glycoprotein function in Hs578T/Dox.

5 July 2018

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Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer

5 July 2018

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An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line

5 July 2018

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Disruption of P-glycoprotein anticancer drug efflux activity by a small recombinant single-chain Fv antibody fragment targeted to an extracellular epitope.

5 July 2018

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Sensitization of cells overexpressing multidrug-resistant proteins by pluronic P85.

5 July 2018

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Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

5 July 2018

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On the Origin of Cancer Cells

5 July 2018

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ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder

5 July 2018

1 reference

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Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines

5 July 2018

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Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein

5 July 2018

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Characterization of a novel metabolic strategy used by drug-resistant tumor cells

5 July 2018

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Pluronic block copolymers for overcoming drug resistance in cancer.

5 July 2018

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Multidrug resistance in cancer: role of ATP-dependent transporters

5 July 2018

1 reference

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Mechanism of sensitization of MDR cancer cells by Pluronic block copolymers: Selective energy depletion

5 July 2018

1 reference

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Endonuclease G is an apoptotic DNase when released from mitochondria

5 July 2018

1 reference

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Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms

5 July 2018

1 reference

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Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

5 July 2018

1 reference

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Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains

5 July 2018

1 reference

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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

5 July 2018

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Molecular characterization of mitochondrial apoptosis-inducing factor

5 July 2018

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A multidrug resistance transporter from human MCF-7 breast cancer cells

5 July 2018

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Functional rafts in cell membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Proton nuclear magnetic resonance spectroscopy reveals cellular lipids involved in resistance to adriamycin and taxol by the K562 leukemia cell line.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Plasma membrane lipid structural order in doxorubicin-sensitive and -resistant P388 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Surfactant-induced sealing of electropermeabilized skeletal muscle membranes in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Prx1 modulates the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Synthesis and characterization of novel thermo-responsive F68 block copolymers with cell-adhesive RGD peptide.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Re-induction of hsp70 synthesis: an assay for thermotolerance. 1988.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

PEO-PPO block copolymer vectors do not interact directly with DNA but with lipid membranes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Lipid composition determines interaction of liposome membranes with Pluronic L61.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Relationship between the structure of amphiphilic copolymers and their ability to disturb lipid bilayers.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Classification analysis of P-glycoprotein substrate specificity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Ionophoric activity of pluronic block copolymers

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Pluronic L61 accelerates flip-flop and transbilayer doxorubicin permeation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL-2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

The relationship between 1H-NMR mobile lipid intensity and cholesterol in two human tumor multidrug resistant cell lines (MCF-7 and LoVo).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Anti-CD19 antibodies inhibit the function of the P-gp pump in multidrug-resistant B lymphoma cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Effect of prooxidants on mitochondrial permeability transition and cell death in Ehrlich ascites tumour cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

Energy metabolism of adriamycin-sensitive and -resistant Ehrlich ascites tumor cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4122590

The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface

29 October 2018

1 reference

12 December 2020

Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells

1 reference

12 December 2020

Surfactant sealing of membranes permeabilized by ionizing radiation

1 reference

12 December 2020

Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy

1 reference

12 December 2020

Effectiveness of poloxamer 188 in arresting calcein leakage from thermally damaged isolated skeletal muscle cells

1 reference

12 December 2020

Nanostructuring PEG-fibrinogen hydrogels to control cellular morphogenesis

1 reference

12 December 2020

Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer

1 reference

12 December 2020

Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells

1 reference

12 December 2020

Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization

1 reference

12 December 2020

Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers

1 reference

12 December 2020

Are cancer stem cells real? After four decades, debate still simmers.

1 reference

12 December 2020

Nanostructuring biosynthetic hydrogels for tissue engineering: A cellular and structural analysis

1 reference

12 December 2020

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

1 reference

12 December 2020

Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents

1 reference

12 December 2020

Identifiers

DOI

10.1021/MP500298Q

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

24950236

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24950236%20AND%20SRC:MED&resulttype=core&format=json