The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo (Q34025103)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24779362%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo (English)

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16 March 2020

5

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16 March 2020

Peter McIntyre

7

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16 March 2020

author name string

M S Grace

1

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16 March 2020

T Lieu

2

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16 March 2020

B Darby

3

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16 March 2020

F C Abogadie

4

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16 March 2020

N W Bunnett

6

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16 March 2020

language of work or name

English

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publication date

1 August 2014

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British Journal of Pharmacology

16 March 2020

published in

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16 March 2020

volume

171

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16 March 2020

issue

16

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16 March 2020

page(s)

3881-3894

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The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors

16 March 2020

cites work

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UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

5 July 2018

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Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

5 July 2018

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N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

5 July 2018

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5 July 2018

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Mutations in TRPV4 cause an inherited arthropathy of hands and feet.

5 July 2018

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Mutant TRPV4-mediated toxicity is linked to increased constitutive function in axonal neuropathies.

5 July 2018

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TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.

5 July 2018

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Bafetinib, a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia

5 July 2018

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Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

5 July 2018

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Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel

5 July 2018

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Identification and characterization of novel TRPV4 modulators

5 July 2018

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Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

5 July 2018

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Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.

5 July 2018

1 reference

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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

5 July 2018

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Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

5 July 2018

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Monoterpenoid agonists of TRPV3

5 July 2018

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Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.

5 July 2018

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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

5 July 2018

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TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

5 July 2018

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WNK kinases influence TRPV4 channel function and localization

5 July 2018

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Overriding imatinib resistance with a novel ABL kinase inhibitor

5 July 2018

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Protease-activated receptors: contribution to physiology and disease

5 July 2018

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Abnormal osmotic regulation in trpv4 -/- mice

5 July 2018

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Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress

5 July 2018

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Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells

5 July 2018

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A TRP channel that senses cold stimuli and menthol

5 July 2018

1 reference

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Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives

5 July 2018

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Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

5 July 2018

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OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

5 July 2018

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Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

5 July 2018

1 reference

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Phosphatidylinositol 3-kinase mediates chemoattractant-stimulated, CD11b/CD18-dependent cell-cell adhesion of human neutrophils: evidence for an ERK-independent pathway.

5 July 2018

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

5 July 2018

1 reference

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Role of Drosophila TRP in inositide-mediated Ca2+ entry

5 July 2018

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Quantitative assessment of tactile allodynia in the rat paw

5 July 2018

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Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction

5 July 2018

1 reference

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A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators.

5 July 2018

1 reference

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

21 January 2018

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Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain.

21 January 2018

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Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.

21 January 2018

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Impaired Pressure Sensation in Mice Lacking TRPV4

21 January 2018

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N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Pa

21 January 2018

1 reference

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

21 January 2018

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Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult

21 January 2018

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Heat-evoked activation of the ion channel, TRPV4.

21 January 2018

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The modulation of TRPV4 channel activity through its Ser 824 residue phosphorylation by SGK1

29 October 2018

1 reference

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24779362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/BPH.12750

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24779362%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24779362%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

24779362

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24779362%20AND%20SRC:MED&resulttype=core&format=json