The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits. (Q34029315)

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English	The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.	scientific article

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5 February 2020

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits (English)

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5 February 2020

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Mhairi C Towler

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Mhairi C Towler

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Daniel Moreno

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Erwin Knecht

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9 June 2010

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Molecular Biology of the Cell

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2578-2588

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Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease

1 reference

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5 July 2018

Lafora disease: insights into neurodegeneration from plant metabolism

1 reference

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5 July 2018

Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin

1 reference

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5 July 2018

RING domain E3 ubiquitin ligases

1 reference

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5 July 2018

Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress

1 reference

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5 July 2018

AMP-activated protein kinase: structure and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

1 reference

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5 July 2018

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

1 reference

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5 July 2018

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

1 reference

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5 July 2018

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes

1 reference

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5 July 2018

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

1 reference

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5 July 2018

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

1 reference

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5 July 2018

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation

1 reference

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5 July 2018

Structural basis for AMP binding to mammalian AMP-activated protein kinase

1 reference

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5 July 2018

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

1 reference

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5 July 2018

Advances in lafora progressive myoclonus epilepsy

1 reference

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5 July 2018

The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment

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5 July 2018

ER stress and diseases.

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5 July 2018

Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates

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5 July 2018

TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase

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5 July 2018

Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?

1 reference

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5 July 2018

Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy

1 reference

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5 July 2018

Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912345

5 July 2018

Regulation of p53 and MDM2 activity by MTBP.

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5 July 2018

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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5 July 2018

Mutations in NHLRC1 cause progressive myoclonus epilepsy

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5 July 2018

Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice

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5 July 2018

A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen

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5 July 2018

A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2)

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Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase

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5 July 2018

Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy

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Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle

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5 July 2018

The structure of a domain common to archaebacteria and the homocystinuria disease protein

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5 July 2018

Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits.

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Is this protein ubiquitinated?

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29 October 2018

Progressive myoclonus epilepsy with polyglucosans (Lafora disease): evidence for a third locus

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29 October 2018

Glucose and type 2A protein phosphatase regulate the interaction between catalytic and regulatory subunits of AMP-activated protein kinase

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29 October 2018

Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis

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12 December 2020

based on heuristic

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Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.E10-03-0227

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5 February 2020

release_ex7p5mhcjnbnfopvcgq3ktvsde

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24 November 2022

based on heuristic

mapped directly with Wikidata item

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Europe PubMed Central

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5 February 2020

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5 February 2020

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