Design and development of a peptide-based adiponectin receptor agonist for cancer treatment (Q34040946)

30 July 2017

Design and development of a peptide-based adiponectin receptor agonist for cancer treatment (English)

1 reference

30 July 2017

John Wade

12

0 references

author name string

Laszlo Otvos

1

1 reference

30 July 2017

Eva Haspinger

2

1 reference

30 July 2017

Francesca La Russa

3

1 reference

30 July 2017

Federica Maspero

4

1 reference

30 July 2017

Patrizia Graziano

5

1 reference

30 July 2017

Ilona Kovalszky

6

1 reference

30 July 2017

Sandor Lovas

7

1 reference

30 July 2017

Kaushik Nama

8

1 reference

30 July 2017

Ralf Hoffmann

9

1 reference

30 July 2017

Daniel Knappe

10

1 reference

30 July 2017

Marco Cassone

11

1 reference

30 July 2017

Eva Surmacz

13

1 reference

30 July 2017

5 October 2011

1 reference

30 July 2017

1 reference

30 July 2017

11

1 reference

30 July 2017

90

1 reference

Creative Commons Attribution 2.0 Generic

30 July 2017

start time

5 October 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3198688/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1186/1472-6750-11-90

0 references

cites work

Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer

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Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion

28 July 2018

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Adipokine regulation of colon cancer: adiponectin attenuates interleukin-6-induced colon carcinoma cell proliferation via STAT-3

28 July 2018

1 reference

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Involvement of the JAK-STAT pathway and SOCS3 in the regulation of adiponectin-generated reactive oxygen species in murine macrophage RAW 264 cells.

28 July 2018

1 reference

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Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)

28 July 2018

1 reference

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The emerging role of adipokines in osteoarthritis: a narrative review

28 July 2018

1 reference

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Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation

28 July 2018

1 reference

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Metformin: a therapeutic opportunity in breast cancer

28 July 2018

1 reference

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Effect of obesity on breast cancer development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Impact of AdipoR1 expression on breast cancer development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

The association of metabolic syndrome with triple-negative breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

The brain is the conductor: diet-induced inflammation overlapping physiological control of body mass and metabolism.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Energy homeostasis and cancer prevention: the AMP-activated protein kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin and cardiovascular disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Targeting AMPK: a new therapeutic opportunity in breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Effects of adiponectin on breast cancer cell growth and signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Antiproliferative effect of adiponectin on MCF7 breast cancer cells: a potential hormonal link between obesity and cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies

28 July 2018

1 reference

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Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Demonstration of adiponectin receptors 1 and 2 mRNA expression in human breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

GROMACS: fast, flexible, and free

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Prostate cancer and adiponectin.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin and adiponectin receptors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adiponectin and breast cancer risk

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Increasing the precision of comparative models with YASARA NOVA-a self-parameterizing force field

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

28 July 2018

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity

28 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adipose tissue as an endocrine organ

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin in insulin resistance: lessons from translational research

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin action from head to toe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin receptor signaling: a new layer to the current model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Serum adiponectin and leptin levels in Taiwanese breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin as a growth inhibitor in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Influence of insulin resistance on adiponectin receptor expression in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Insulin-dependent leptin expression in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1472-6750-11-90

Circulating markers of angiogenesis, inflammation, and coagulation in patients with glioblastoma.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Metastasis suppression by adiponectin: LKB1 rises up to the challenge

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adipocytokines and breast cancer risk

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Adipocytokines and cancer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3198688

Globular adiponectin activates nuclear factor-kappaB in vascular endothelial cells, which in turn induces expression of proinflammatory and adhesion molecule genes

28 October 2018

1 reference

12 December 2020

Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3

1 reference

12 December 2020

1 reference

12 December 2020

Association of serum adiponectin levels with breast cancer risk

1 reference

12 December 2020

Peptide stability in drug development: a comparison of peptide reactivity in different biological media

1 reference

12 December 2020

Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells

1 reference

12 December 2020

Identifiers

DOI

10.1186/1472-6750-11-90

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference