Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion (Q34231901)

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English	Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion (English)

1 reference

Europe PubMed Central

31 July 2017

phosphorylation

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

Michael B. Wheeler

object named as

Michael B Wheeler

6

0 references

author name string

Nadeeja Wijesekara

1

1 reference

Europe PubMed Central

31 July 2017

Mansa Krishnamurthy

2

1 reference

Europe PubMed Central

31 July 2017

Alpana Bhattacharjee

3

1 reference

Europe PubMed Central

31 July 2017

Aamir Suhail

4

1 reference

Europe PubMed Central

31 July 2017

Gary Sweeney

5

1 reference

Europe PubMed Central

31 July 2017

language of work or name

0 references

publication date

13 August 2010

1 reference

Europe PubMed Central

31 July 2017

number of pages

9

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

31 July 2017

285

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Europe PubMed Central

31 July 2017

33623-33631

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Europe PubMed Central

31 July 2017

44

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Europe PubMed Central

31 July 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2962460/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Adiponectin reduces glucotoxicity-induced apoptosis of INS-1 rat insulin-secreting cells on a microfluidic chip

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

APPL1: role in adiponectin signaling and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Adiponectin--a key adipokine in the metabolic syndrome

1 reference

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Adiponectin: a key adipocytokine in metabolic syndrome

1 reference

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Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis

1 reference

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6 July 2018

Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis

1 reference

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Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms

1 reference

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6 July 2018

Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription

1 reference

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6 July 2018

Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1.

1 reference

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6 July 2018

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

1 reference

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T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin

1 reference

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6 July 2018

Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Expression of adiponectin receptors in pancreatic beta cells

1 reference

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A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity

1 reference

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6 July 2018

Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

1 reference

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Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

1 reference

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6 July 2018

Disruption of adiponectin causes insulin resistance and neointimal formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

1 reference

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Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin.

1 reference

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

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Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription

1 reference

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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

6 July 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase

1 reference

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A novel serum protein similar to C1q, produced exclusively in adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Regulation of adiponectin receptor 2 expression via PPAR-alpha in NIT-1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.

1 reference

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Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.

1 reference

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28 October 2018

Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

28 October 2018

Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications

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Dual action of adiponectin on insulin secretion in insulin-resistant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

28 October 2018

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

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1 reference

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AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2962460

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Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20709750

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based on heuristic

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Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20709750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Globular adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20709750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20709750

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.085084

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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