Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors (Q34045737)

30 July 2017

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors (English)

1 reference

30 July 2017

0 references

2

1 reference

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10 June 2020

Haiming Dai

4

1 reference

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10 June 2020

11

Jonathan D Wren

1 reference

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10 June 2020

author name string

Yi Zhu

1

1 reference

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10 June 2020

Heike Fuhrmann-Stroissnigg

3

1 reference

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10 June 2020

Yuanyuan Y Ling

5

1 reference

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10 June 2020

Michael B Stout

6

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10 June 2020

Tamar Pirtskhalava

7

1 reference

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10 June 2020

Nino Giorgadze

8

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10 June 2020

Kurt O Johnson

9

1 reference

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10 June 2020

Cory B Giles

10

1 reference

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10 June 2020

Laura J Niedernhofer

12

1 reference

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10 June 2020

Paul D Robbins

13

1 reference

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10 June 2020

James L Kirkland

14

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10 June 2020

publication date

29 December 2015

1 reference

30 July 2017

1 reference

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10 June 2020

volume

15

1 reference

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10 June 2020

page(s)

428-435

1 reference

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10 June 2020

issue

3

1 reference

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Targeting senescent cells enhances adipogenesis and metabolic function in old age

10 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Targeting BCL2-Proteins for the Treatment of Solid Tumours

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

New resistance mechanisms for small molecule kinase inhibitors of Abl kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

BH3 mimetics: status of the field and new developments

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Fat tissue, aging, and cellular senescence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Control of apoptosis by p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4854923

Aging, depot origin, and preadipocyte gene expression

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FACEL.12445

21 January 2018

Identifiers

DOI

10.1111/ACEL.12445

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26711051%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

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10 June 2020

1 reference

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