Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. (Q38172752)

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3 March 2020

title

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy (English)

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3 March 2020

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3

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3 March 2020

Jerry Adams

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4

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3 March 2020

author name string

Peter E Czabotar

series ordinal

1

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3 March 2020

Guillaume Lessene

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2

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3 March 2020

publication date

1 January 2014

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Nature Reviews Molecular Cell Biology

3 March 2020

published in

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3 March 2020

volume

15

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3 March 2020

page(s)

49-63

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3 March 2020

issue

1

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https://scigraph.springernature.com/pub.10.1038/nrm3722

3 March 2020

exact match

0 references

cites work

Cell death in us and others

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Myc-driven endogenous cell competition in the early mammalian embryo

31 March 2020

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An evolutionary perspective on apoptosis.

31 March 2020

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

31 March 2020

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Autoimmunity and the clearance of dead cells

31 March 2020

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31 March 2020

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Alternative cell death mechanisms in development and beyond

31 March 2020

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The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.

31 March 2020

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

31 March 2020

1 reference

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

31 March 2020

1 reference

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

31 March 2020

1 reference

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

31 March 2020

1 reference

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

31 March 2020

1 reference

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

31 March 2020

1 reference

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

31 March 2020

1 reference

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

31 March 2020

1 reference

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

31 March 2020

1 reference

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

31 March 2020

1 reference

The many roles of FAS receptor signaling in the immune system

31 March 2020

1 reference

The apoptosome: signalling platform of cell death

31 March 2020

1 reference

Mitochondria and cell death: outer membrane permeabilization and beyond

31 March 2020

1 reference

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

31 March 2020

1 reference

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

31 March 2020

1 reference

Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

31 March 2020

1 reference

31 March 2020

The BCL-2 family reunion

1 reference

Bcl-2 family members: dual regulators of apoptosis and autophagy

31 March 2020

1 reference

Delving deeper: MCL-1's contributions to normal and cancer biology

31 March 2020

1 reference

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

31 March 2020

1 reference

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

31 March 2020

1 reference

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

31 March 2020

1 reference

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

1 reference

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

31 March 2020

1 reference

XIAP discriminates between type I and type II FAS-induced apoptosis

31 March 2020

1 reference

Solution structure of BID, an intracellular amplifier of apoptotic signaling

31 March 2020

1 reference

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

31 March 2020

1 reference

The Bcl-2 apoptotic switch in cancer development and therapy

31 March 2020

1 reference

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

31 March 2020

1 reference

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

31 March 2020

1 reference

A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

31 March 2020

1 reference

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 March 2020

1 reference

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

1 reference

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

31 March 2020

1 reference

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

31 March 2020

1 reference

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

31 March 2020

1 reference

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

1 reference

BAX activation is initiated at a novel interaction site

31 March 2020

1 reference

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

1 reference

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

31 March 2020

1 reference

Structural insights into the degradation of Mcl-1 induced by BH3 domains

31 March 2020

1 reference

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

31 March 2020

1 reference

Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).

31 March 2020

1 reference

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

31 March 2020

1 reference

Structural plasticity underpins promiscuous binding of the prosurvival protein A1

31 March 2020

1 reference

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

31 March 2020

1 reference

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

31 March 2020

1 reference

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

31 March 2020

1 reference

Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist

31 March 2020

1 reference

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

31 March 2020

1 reference

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

31 March 2020

1 reference

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

31 March 2020

1 reference

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

31 March 2020

1 reference

Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

1 reference

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

31 March 2020

1 reference

Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming

31 March 2020

1 reference

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

31 March 2020

1 reference

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

31 March 2020

1 reference

Direct activation of full-length proapoptotic BAK

31 March 2020

1 reference

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

31 March 2020

1 reference

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

31 March 2020

1 reference

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

31 March 2020

1 reference

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

31 March 2020

1 reference

BID-induced structural changes in BAK promote apoptosis

31 March 2020

1 reference

Nonionic detergents induce dimerization among members of the Bcl-2 family

31 March 2020

1 reference

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

31 March 2020

1 reference

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

31 March 2020

1 reference

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis

31 March 2020

1 reference

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

31 March 2020

1 reference

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

31 March 2020

1 reference

Molecular details of Bax activation, oligomerization, and membrane insertion.

31 March 2020

1 reference

Bax forms an oligomer via separate, yet interdependent, surfaces

31 March 2020

1 reference

Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers

31 March 2020

1 reference

Apoptosis: embedded in membranes

31 March 2020

1 reference

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

31 March 2020

1 reference

Molecular biology of Bax and Bak activation and action

31 March 2020

1 reference

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

31 March 2020

1 reference

Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

31 March 2020

1 reference

Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size

31 March 2020

1 reference

Cytoplasmic functions of the tumour suppressor p53.

31 March 2020

1 reference

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

31 March 2020

1 reference

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

31 March 2020

1 reference

Regulation of Bcl-2 family proteins by posttranslational modifications.

31 March 2020

1 reference

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

31 March 2020

1 reference

Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance.

31 March 2020

1 reference

Mcl-1; the molecular regulation of protein function

31 March 2020

1 reference

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

31 March 2020

1 reference

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

31 March 2020

1 reference

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

31 March 2020

1 reference

The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment

31 March 2020

1 reference

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

31 March 2020

1 reference

Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.

31 March 2020

1 reference

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

31 March 2020

1 reference

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

1 reference

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

31 March 2020

1 reference

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

1 reference

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

31 March 2020

1 reference

Programmed anuclear cell death delimits platelet life span.

31 March 2020

1 reference

Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.

31 March 2020

1 reference

Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice

31 March 2020

1 reference

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

31 March 2020

1 reference

Testicular degeneration in Bclw-deficient mice

31 March 2020

1 reference

BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity

31 March 2020

1 reference

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

31 March 2020

1 reference

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

31 March 2020

1 reference

Mcl-1 is essential for germinal center formation and B cell memory

31 March 2020

1 reference

Mcl-1 is essential for the survival of plasma cells

31 March 2020

1 reference

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

31 March 2020

1 reference

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

31 March 2020

1 reference

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

31 March 2020

1 reference

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

31 March 2020

1 reference

The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

1 reference

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

1 reference

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

1 reference

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

31 March 2020

1 reference

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

31 March 2020

1 reference

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

31 March 2020

1 reference

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

31 March 2020

1 reference

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

31 March 2020

1 reference

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

31 March 2020

1 reference

PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

1 reference

PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

1 reference

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

31 March 2020

1 reference

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

1 reference

Integral role of Noxa in p53-mediated apoptotic response

31 March 2020

1 reference

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

31 March 2020

1 reference

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa

31 March 2020

1 reference

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

31 March 2020

1 reference

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development

31 March 2020

1 reference

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

31 March 2020

1 reference

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

31 March 2020

1 reference

Bad-deficient mice develop diffuse large B cell lymphoma

31 March 2020

1 reference

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

31 March 2020

1 reference

Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.

31 March 2020

1 reference

Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

31 March 2020

1 reference

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

31 March 2020

1 reference

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

31 March 2020

1 reference

BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

31 March 2020

1 reference

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

31 March 2020

1 reference

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

1 reference

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

31 March 2020

1 reference

Consequences of the combined loss of BOK and BAK or BOK and BAX.

31 March 2020

1 reference

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

31 March 2020

1 reference

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

1 reference

Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

1 reference

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

31 March 2020

1 reference

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

31 March 2020

1 reference

Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.

31 March 2020

1 reference

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

31 March 2020

1 reference

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

31 March 2020

1 reference

The landscape of somatic copy-number alteration across human cancers

31 March 2020

1 reference

Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

31 March 2020

1 reference

Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance.

31 March 2020

1 reference

Multistep pathogenesis of autoimmune disease.

31 March 2020

1 reference

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

31 March 2020

1 reference

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

31 March 2020

1 reference

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.

31 March 2020

1 reference

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

31 March 2020

1 reference

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

31 March 2020

1 reference

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

31 March 2020

1 reference

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

31 March 2020

1 reference

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

31 March 2020

1 reference

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

31 March 2020

1 reference

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

31 March 2020

1 reference

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

31 March 2020

1 reference

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

31 March 2020

1 reference

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

31 March 2020

1 reference

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

31 March 2020

1 reference

BCL-2 family antagonists for cancer therapy

31 March 2020

1 reference

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

1 reference

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

1 reference

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

31 March 2020

1 reference

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

31 March 2020

1 reference

Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models

31 March 2020

1 reference

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

31 March 2020

1 reference

Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

31 March 2020

1 reference

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

31 March 2020

1 reference

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

31 March 2020

1 reference

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

31 March 2020

1 reference

Structure-guided design of a selective BCL-X(L) inhibitor

31 March 2020

1 reference

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

31 March 2020

1 reference

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

31 March 2020

1 reference

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

31 March 2020

1 reference

Mcl-1 is required for melanoma cell resistance to anoikis

31 March 2020

1 reference

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

31 March 2020

1 reference

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

31 March 2020

1 reference

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

31 March 2020

1 reference

The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity.

31 March 2020

1 reference

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

31 March 2020

1 reference

Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes

31 March 2020

1 reference

Direct and selective small-molecule activation of proapoptotic BAX

31 March 2020

1 reference

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

31 March 2020

1 reference

Shedding light on apoptosis at subcellular membranes

31 March 2020

1 reference

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

31 March 2020

1 reference

Role of Bax and Bak in mitochondrial morphogenesis

31 March 2020

1 reference

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

31 March 2020

1 reference

Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential

31 March 2020

1 reference

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

1 reference

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

1 reference

Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.

31 March 2020

1 reference

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

31 March 2020

1 reference

The structure of Boo/Diva reveals a divergent Bcl-2 protein

31 March 2020

1 reference

12 December 2020

Mechanisms of action of Bcl-2 family proteins

1 reference

12 December 2020

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1 reference

12 December 2020

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1 reference

12 December 2020

Mcl-1 deficiency results in peri-implantation embryonic lethality

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM3722

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24355989%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24355989%20AND%20SRC:MED&resulttype=core&format=json