Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint. (Q34069364)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9445009%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

title

Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint (English)

1 reference

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8 November 2019

author name string

J T Thomas

series ordinal

1

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8 November 2019

L A Laimins

series ordinal

2

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8 November 2019

language of work or name

English

0 references

publication date

1 February 1998

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8 November 2019

1 reference

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8 November 2019

volume

72

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8 November 2019

issue

2

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8 November 2019

page(s)

1131-1137

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Initiation of DNA synthesis by human papillomavirus E7 oncoproteins is resistant to p21-mediated inhibition of cyclin E-cdk2 activity

8 November 2019

cites work

1 reference

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Regulation of p53 stability by Mdm2

5 July 2018

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Mdm2 promotes the rapid degradation of p53

5 July 2018

1 reference

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Perturbation of the p53 response by human papillomavirus type 16 E7.

5 July 2018

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Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21

5 July 2018

1 reference

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Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation.

5 July 2018

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5 July 2018

p53: puzzle and paradigm

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

5 July 2018

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Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

5 July 2018

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In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression

5 July 2018

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Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation

5 July 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

5 July 2018

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mdm2 expression is induced by wild type p53 activity

5 July 2018

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

5 July 2018

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Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

5 July 2018

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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

5 July 2018

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Human papillomavirus type 16 E7 associates with a histone H1 kinase and with p107 through sequences necessary for transformation

5 July 2018

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The p53-mdm-2 autoregulatory feedback loop

5 July 2018

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Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene

5 July 2018

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Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

5 July 2018

1 reference

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WAF1, a potential mediator of p53 tumor suppression

5 July 2018

1 reference

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

5 July 2018

1 reference

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Inhibition of p53 DNA binding by human papillomavirus E6 proteins

5 July 2018

1 reference

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Functions of human papillomavirus proteins.

5 July 2018

1 reference

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Epidemiology of cervical human papillomavirus infections

5 July 2018

1 reference

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In vitro systems for the study and propagation of human papillomaviruses

5 July 2018

1 reference

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Human pathogenic papillomavirus types: an update

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

5 July 2018

1 reference

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The biology of human papillomaviruses: from warts to cancer.

5 July 2018

1 reference

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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Genital human papillomavirus infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.

5 July 2018

1 reference

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Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells

5 July 2018

1 reference

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Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Interactions between papillomavirus proteins and tumor suppressor gene products.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

5 July 2018

Human papillomaviruses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Interaction between the retinoblastoma protein and the oncoprotein MDM2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The retinoblastoma protein and cell cycle control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The p53 tumour suppressor gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The E2F transcription factor is a cellular target for the RB protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Amplification of a gene encoding a p53-associated protein in human sarcomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Cancer. p53, guardian of the genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

5 July 2018

1 reference

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The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

5 July 2018

1 reference

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Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124587

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

5 July 2018

1 reference

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

28 October 2018

1 reference

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DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

28 October 2018

1 reference

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Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation.

28 October 2018

1 reference

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DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6

28 October 2018

1 reference

12 December 2020

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1 reference

12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

12 December 2020

A p53-dependent mouse spindle checkpoint

1 reference

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9445009%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

1 reference