SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. (Q34072652)

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English	SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway.	scientific article

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17 January 2020

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway (English)

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17 January 2020

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Mona Dvir-Ginzberg

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17 January 2020

Michael J. Quon

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17 January 2020

Michael J. Quon

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17 January 2020

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Viktoria Gagarina

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17 January 2020

Odile Gabay

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17 January 2020

Eun Jin Lee

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17 January 2020

Jillian K Brady

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17 January 2020

David J Hall

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1 May 2010

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17 January 2020

Arthritis and Rheumatism

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17 January 2020

62

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17 January 2020

5

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17 January 2020

1383-1392

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17 January 2020

Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.

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5 July 2018

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

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5 July 2018

A brief introduction to FOXOlogy

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FOXO transcription factors in ageing and cancer.

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5 July 2018

Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins

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5 July 2018

Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

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5 July 2018

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

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5 July 2018

AKT/PKB signaling: navigating downstream

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SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

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5 July 2018

MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells

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IGF-I mediated survival pathways in normal and malignant cells

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Matrix metalloproteinases: role in arthritis

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5 July 2018

Kinase signaling cascades in the mitochondrion: a matter of life or death.

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Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury

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5 July 2018

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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5 July 2018

The Sir2 family of protein deacetylases

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5 July 2018

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

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5 July 2018

Mammalian SIRT1 represses forkhead transcription factors

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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5 July 2018

Cell death in cartilage.

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5 July 2018

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

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5 July 2018

Metalloproteases and inhibitors in arthritic diseases

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5 July 2018

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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5 July 2018

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

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5 July 2018

Negative control of p53 by Sir2alpha promotes cell survival under stress

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5 July 2018

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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5 July 2018

Apoptosis in normal and osteoarthritic human articular cartilage

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5 July 2018

Apoptotic chondrocyte death in human osteoarthritis.

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5 July 2018

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

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5 July 2018

Growth factor actions on articular cartilage

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5 July 2018

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

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28 October 2018

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

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28 October 2018

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

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28 October 2018

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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28 October 2018

Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1

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12 December 2020

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Protein-tyrosine phosphatases PTP1B and syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

based on heuristic

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Apoptotic chondrocytes from osteoarthrotic human articular cartilage and abnormal calcification of subchondral bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

based on heuristic

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Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc

1 reference

https://pubmed.ncbi.nlm.nih.gov/20131294

12 December 2020

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Identifiers

10.1002/ART.27369

1 reference

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17 January 2020

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17 January 2020

1 reference

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17 January 2020

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