SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication (Q34073816)

30 July 2017

title

SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication (English)

1 reference

30 July 2017

1 reference

Fares Al-Ejeh

3

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David F. Callen

object named as

David F Callen

5

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author name string

Pegah Johansson

1

1 reference

30 July 2017

Jessie Jeffery

2

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30 July 2017

Renèe B Schulz

4

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30 July 2017

Raman Kumar

6

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30 July 2017

Kum Kum Khanna

7

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30 July 2017

language of work or name

English

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publication date

14 May 2014

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Journal of Biological Chemistry

30 July 2017

published in

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30 July 2017

volume

289

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30 July 2017

issue

26

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30 July 2017

page(s)

18514-18525

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The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration

30 July 2017

cites work

1 reference

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Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.

28 July 2018

1 reference

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Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor

28 July 2018

1 reference

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F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

28 July 2018

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Identification of SCF ubiquitin ligase substrates by global protein stability profiling

28 July 2018

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In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.

28 July 2018

1 reference

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Proximity ligation: a specific and versatile tool for the proteomic era.

28 July 2018

1 reference

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Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

28 July 2018

1 reference

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Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.

28 July 2018

1 reference

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Ubiquitin ligases: cell-cycle control and cancer

28 July 2018

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FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex

28 July 2018

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NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Preventing re-replication of chromosomal DNA.

28 July 2018

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Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase

28 July 2018

1 reference

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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

28 July 2018

1 reference

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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

28 July 2018

1 reference

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Systematic analysis and nomenclature of mammalian F-box proteins

28 July 2018

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The SCF ubiquitin ligase: insights into a molecular machine

28 July 2018

1 reference

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Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

A p53-dependent checkpoint pathway prevents rereplication

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Protein detection using proximity-dependent DNA ligation assays.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Oncogenic potential of the DNA replication licensing protein CDT1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

The ubiquitin-proteasome pathway and pathogenesis of human diseases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

FBXO31 determines poor prognosis in esophageal squamous cell carcinoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

FBXO31 is down-regulated and may function as a tumor suppressor in hepatocellular carcinoma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Regulation of Skp2 expression and activity and its role in cancer progression

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Origin recognition and the chromosome cycle

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140253

Loss of heterozygosity at chromosomes 3, 6, 8, 11, 16, and 17 in ovarian cancer: correlation to clinicopathological variables

28 October 2018

1 reference

12 December 2020

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

1 reference

12 December 2020

Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts

1 reference

12 December 2020

Deletion mapping of chromosome 16q24 in hepatocellular carcinoma in Taiwan and mutational analysis of the 17-beta-HSD gene localized to the region

1 reference

12 December 2020

Loss of heterozygosity in chromosomal region 16q24.3 associated with progression of prostate cancer

1 reference

12 December 2020

SnapShot: F Box Proteins II

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.559930

1 reference

30 July 2017

1 reference

30 July 2017

1 reference