Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo (Q34078624)

30 July 2017

Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo (English)

1 reference

SOS Ras/Rac guanine nucleotide exchange factor 1

30 July 2017

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

2

Harvey F Lodish

1 reference

30 July 2017

Jing Zhang

1

1 reference

PubMed ID

16203968

30 July 2017

language of work or name

English

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publication date

3 October 2005

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30 July 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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30 July 2017

102

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30 July 2017

41

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30 July 2017

14605-14610

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PubMed ID

16203968

describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1253609/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

5 July 2018

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Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

5 July 2018

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While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

5 July 2018

1 reference

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development

5 July 2018

1 reference

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Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

5 July 2018

1 reference

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

5 July 2018

1 reference

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

5 July 2018

1 reference

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5 July 2018

Kit signal transduction

1 reference

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H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

5 July 2018

1 reference

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

5 July 2018

1 reference

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Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

5 July 2018

1 reference

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

5 July 2018

1 reference

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

5 July 2018

1 reference

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Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation

5 July 2018

1 reference

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of Grb2 by phage display

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Mechanism of activation of protein kinase B by insulin and IGF-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

The murine N-ras gene is not essential for growth and development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

5 July 2018

1 reference

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Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice

5 July 2018

1 reference

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Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

5 July 2018

1 reference

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Simplified mammalian DNA isolation procedure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1253609

The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507446102

Ras signalling on the endoplasmic reticulum and the Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507446102

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507446102

Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507446102

K-Ras is essential for normal fetal liver erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507446102

Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0507446102

K-ras is essential for the development of the mouse embryo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16203968

12 December 2020

inferred from PubMed ID database lookup

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16203968

12 December 2020

inferred from PubMed ID database lookup

Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16203968

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0507446102

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference

PubMed ID

16203968