In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase (Q34080500)

30 July 2017

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title

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase (English)

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30 July 2017

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Howlett DR

1

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30 July 2017

Simmons DL

series ordinal

2

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30 July 2017

Dingwall C

series ordinal

3

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30 July 2017

Christie G

series ordinal

4

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30 July 2017

publication date

1 November 2000

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30 July 2017

published in

Trends in Neurosciences

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30 July 2017

volume

23

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30 July 2017

issue

11

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30 July 2017

page(s)

565-570

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

30 July 2017

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7 January 2021

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Putative N-terminal splitting enzyme of amyloid A4 peptides is the multicatalytic proteinase, ingensin, which is widely distributed in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Expression and characterization of human beta-secretase candidates metalloendopeptidase MP78 and cathepsin D in beta APP-overexpressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Metalloprotease MP100: a synaptic protease in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Cathepsin D displays in vitro beta-secretase-like specificity.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Expression analysis of BACE2 in brain and peripheral tissues

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

HIV protease as an inhibitor target for the treatment of AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Dose-Dependent Effects of the Renin Inhibitor Zankiren HCl After a Single Oral Dose in Mildly Sodium-Depleted Normotensive Subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Discovery of inhibitors of human renin with high oral bioavailability

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

Alzheimer's disease. A firm base for drug development.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2800%2901647-7

7 January 2021

10.1016/S0166-2236(00)01647-7

Identifiers

DOI

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30 July 2017

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