Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation (Q34086610)

30 July 2017

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation (English)

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30 July 2017

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Richard J Wheeler

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Daniel Coombs

object named as

Daniel Coombs

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Vincenzo Cerundolo

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Vincenzo Cerundolo

Philip Anton van der Merwe

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P Anton van der Merwe

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30 July 2017

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Omer Dushek

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30 July 2017

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Shaun-Paul Cordoba

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30 July 2017

Milos Aleksic

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30 July 2017

Hao Zhang

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30 July 2017

Yan-Chun Peng

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30 July 2017

Ji-Li Chen

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30 July 2017

Tao Dong

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30 July 2017

7 June 2011

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176

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30 July 2017

ra39

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Strength of TCR-peptide/MHC interactions and in vivo T cell responses

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Studying Molecular Interactions at the Single Bond Level with a Laminar Flow Chamber

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Mechanisms for T cell receptor triggering

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Attenuated T cell responses to a high-potency ligand in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

The Goldilocks model for TCR-too much attraction might not be best for vaccine design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Fast on-rates allow short dwell time ligands to activate T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

A role for rebinding in rapid and reliable T cell responses to antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Digital signaling and hysteresis characterize ras activation in lymphoid cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Drug-target residence time and its implications for lead optimization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Soluble T cell receptors: novel immunotherapies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

T cell cross-reactivity and conformational changes during TCR engagement

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Altered T cell receptor ligands trigger a subset of early T cell signals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Kinetic proofreading in T-cell receptor signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Models for the Specific Adhesion of Cells to Cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

A Response Calculus for Immobilized T Cell Receptor Ligands

5 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001430

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001430

Directed evolution of human T-cell receptors with picomolar affinities by phage display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001430

Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001430

The reaction between acetyl choline and muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2001430

The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143974

Activated TCRs remain marked for internalization after dissociation from pMHC

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21653229

12 December 2020

inferred from PubMed ID database lookup

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21653229

12 December 2020

inferred from PubMed ID database lookup

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21653229

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1126/SCISIGNAL.2001430

1 reference

release_jj7etigq4ngzbmjiq3djrdvhuy

30 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jj7etigq4ngzbmjiq3djrdvhuy

24 November 2022

mapped directly with Wikidata item

PMCID

4143974

1 reference

30 July 2017

1 reference