Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells. (Q34086998)

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English	Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.	scientific article

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21 February 2020

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells (English)

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21 February 2020

Michael G. Strainic

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21 February 2020

Ethan M. Shevach

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Ethan M Shevach

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21 February 2020

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Fengqi An

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21 February 2020

Feng Lin

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21 February 2020

M Edward Medof

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21 February 2020

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23 December 2012

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21 February 2020

Nature Immunology

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21 February 2020

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21 February 2020

162-171

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21 February 2020

2

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21 February 2020

Regulation and function of mTOR signalling in T cell fate decisions

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A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity

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IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo

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Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation

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PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

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28 July 2018

The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.

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28 July 2018

C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

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The initial phase of an immune response functions to activate regulatory T cells

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Mechanisms of foxp3+ T regulatory cell-mediated suppression

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Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells

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Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells

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Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

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21 January 2018

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12 December 2020

based on heuristic

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Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoinduction of mRNA and protein expression for transforming growth factor-beta S in cultured cardiac cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23263555

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

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10.1038/NI.2499

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21 February 2020

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21 February 2020

1 reference

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21 February 2020

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