A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function (Q34091121)

30 July 2017

A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function (English)

1 reference

30 July 2017

Rajeev Mehla

1

1 reference

30 July 2017

Shalmali Bivalkar-Mehla

series ordinal

2

1 reference

30 July 2017

Ashok Chauhan

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

30 November 2011

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30 July 2017

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30 July 2017

6

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30 July 2017

11

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30 July 2017

e27915

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Creative Commons Attribution 4.0 International

30 July 2017

start time

30 November 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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28 July 2018

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28 July 2018

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28 July 2018

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Short communication: dynamic constraints on the second phase compartment of HIV-infected cells

28 July 2018

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A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5

28 July 2018

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Luteolin suppresses IL-1beta-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982.

28 July 2018

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Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner

28 July 2018

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Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155.

28 July 2018

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Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis

28 July 2018

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Naturally occurring variability in the envelope glycoprotein of HIV-1 and development of cell entry inhibitors

28 July 2018

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HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry

28 July 2018

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Nonpolymorphic human immunodeficiency virus type 1 protease and reverse transcriptase treatment-selected mutations.

28 July 2018

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9-Aminoacridine inhibition of HIV-1 Tat dependent transcription

28 July 2018

1 reference

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Proteomic identification of anti-cancer proteins in luteolin-treated human hepatoma Huh-7 cells

28 July 2018

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Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin

28 July 2018

1 reference

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Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

28 July 2018

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HIV-1 drug resistance mutations: an updated framework for the second decade of HAART

28 July 2018

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Analyzing real-time PCR data by the comparative C(T) method

28 July 2018

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Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

28 July 2018

1 reference

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Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages

28 July 2018

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Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins

28 July 2018

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The taming of the cell penetrating domain of the HIV Tat: myths and realities

28 July 2018

1 reference

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The design, synthesis, and biological evaluation of novel substituted purines as HIV-1 Tat-TAR inhibitors

28 July 2018

1 reference

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Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Molecular mechanisms of HIV-1 associated neurodegeneration

28 July 2018

1 reference

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Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity

28 July 2018

1 reference

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Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.

28 July 2018

1 reference

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Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Dynamics of HIV-1 recombination in its natural target cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport

28 July 2018

1 reference

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Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

A quantitative assay for HIV DNA integration in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Inhibitory activity of flavonoids and tannins against HIV-1 protease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

HIV-1 tat transcriptional activity is regulated by acetylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Inhibition of human immunodeficiency virus type 1 replication and cytokine production by fluoroquinoline derivatives.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

HIV-1 integrase inhibitory substances from Coleus parvifolius.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Analysis of human immunodeficiency virus type 1 integration by using a specific, sensitive and quantitative assay based on real-time polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Cell cycle regulation of human immunodeficiency virus type 1 integration in T cells: antagonistic effects of nuclear envelope breakdown and chromatin condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Amino acid sequence divergence of Tat protein (exon1)of subtype B and C HIV-1 strains: Does it have implications for vaccine development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Human immunodeficiency virus type 1 subtype C exhibits higher transactivation activity of Tat than subtypes B and E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Blocking HIV replication by targeting Tat protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Quantification of tear proteins and sPLA2-IIa alteration in patients with allergic conjunctivitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0027915

Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227592

Intracellular trafficking and interactions of the HIV-1 Tat protein

28 October 2018

1 reference

12 December 2020

Antiviral activity of flavones and potentiation by ascorbate

1 reference

12 December 2020

Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes

1 reference

12 December 2020

A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer

1 reference

12 December 2020

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

1 reference

12 December 2020

Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats

1 reference

12 December 2020

Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation

1 reference

12 December 2020

Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

1 reference

12 December 2020

Luteolin isolated from the medicinal plant Elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0027915

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30 July 2017

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30 July 2017

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