Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy (Q34714816)

4 August 2017

1 reference

title

Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy (English)

1 reference

4 August 2017

Warner C Greene

1

1 reference

PubMed ID

12091904

4 August 2017

B Matija Peterlin

series ordinal

2

1 reference

PubMed ID

12091904

4 August 2017

language of work or name

English

0 references

publication date

1 July 2002

1 reference

4 August 2017

1 reference

4 August 2017

8

1 reference

4 August 2017

673-680

1 reference

4 August 2017

7

1 reference

https://scigraph.springernature.com/pub.10.1038/nm0702-673

4 August 2017

0 references

cites work

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

A block to human immunodeficiency virus type 1 assembly in murine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Retroviruses as model systems for the study of nuclear RNA export pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The plasma membrane as a combat zone in the HIV battlefield

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV entry and its inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Lipid rafts and HIV-1: from viral entry to assembly of progeny virions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Global distribution of the CCR5 gene 32-basepair deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Endocytic entry of HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Specific incorporation of cyclophilin A into HIV-1 virions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Role of Vif in stability of the human immunodeficiency virus type 1 core

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Evidence for a newly discovered cellular anti-HIV-1 phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Accumulation and intranuclear distribution of unintegrated human immunodeficiency virus type 1 DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Transport routes through the nuclear pore complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

A novel nuclear export activity in HIV-1 matrix protein required for viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The barrier-to-autointegration protein is a host factor for HIV type 1 integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Control of RNA initiation and elongation at the HIV-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Nef increases infectivity of HIV via lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Structure--function relationships in HIV-1 Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

HIV-1 gag proteins: diverse functions in the virus life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Organization of immature human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Identification of a host protein essential for assembly of immature HIV-1 capsids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Plasma membrane rafts play a critical role in HIV-1 assembly and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

A role for ubiquitin ligase recruitment in retrovirus release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Unexpectedly high levels of HIV-1 RNA and protein synthesis in a cytocidal infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

Identification of three major phosphorylation sites within HIV-1 capsid. Role of phosphorylation during the early steps of infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

Characterization of HIV replication complexes early after cell-to-cell infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

HIV-1 genome nuclear import is mediated by a central DNA flap

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

Cellular protein modulates effects of human immunodeficiency virus type 1 Rev

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0702-673

7 January 2021

Identifiers

DOI

10.1038/NM0702-673

1 reference

4 August 2017

1 reference

PubMed ID

12091904