Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? (Q34099969)

31 July 2017

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title

Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? (English)

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31 July 2017

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Lucienne Chatenoud

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publication date

1 March 2010

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Nature Reviews Endocrinology

31 July 2017

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31 July 2017

6

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3

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31 July 2017

149-157

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https://scigraph.springernature.com/pub.10.1038/nrendo.2009.275

31 July 2017

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A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

31 March 2020

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31 March 2020

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

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Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group

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31 March 2020

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Chronic intravenous injections of antigen induce and maintain tolerance in T cell receptor-transgenic mice

31 March 2020

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Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription

31 March 2020

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Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277

31 March 2020

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Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens

31 March 2020

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Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens

31 March 2020

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Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice

31 March 2020

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Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

31 March 2020

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CD3-specific antibody-induced active tolerance: from bench to bedside

31 March 2020

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CD3-specific antibodies: a portal to the treatment of autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

31 March 2020

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Transforming growth factor-beta and T-cell-mediated immunoregulation in the control of autoimmune diabetes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Transforming growth factor-beta regulation of immune responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Tolerogenic dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Tolerogenic dendritic cells: cytokine modulation comes of age.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Reduction of morbidity and cytokine release in anti-CD3 MoAb-treated mice by corticosteroids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Cascade modulation by anti-tumor necrosis factor monoclonal antibody of interferon-γ, interleukin 3 and interleukin 6 release after triggering of the CD33/T cell receptor activation pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Anti-tumor necrosis factor modulates anti-CD3-triggered T cell cytokine gene expression in vivo

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Evidence that antihuman tumor necrosis factor monoclonal antibody prevents OKT3-induced acute syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

beta-cell failure in diabetes and preservation by clinical treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Natural versus adaptive regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

CD4+ CD25+ suppressor T cells: more questions than answers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2009.275

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells

31 March 2020

1 reference

12 December 2020

Autoimmune diabetes mellitus in the BB rat

1 reference

12 December 2020

Induction of glutamic acid decarboxylase 65-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent

1 reference

12 December 2020

The mechanism of immunological paralysis.

1 reference

12 December 2020

Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

1 reference

12 December 2020

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen

1 reference

12 December 2020

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

1 reference

12 December 2020

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.

1 reference

12 December 2020

Insulin-dependent diabetes mellitus as an autoimmune disease

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2009.275

1 reference

31 July 2017

1 reference

PubMed ID

20173776