Mitochondrial dysfunction and intracellular calcium dysregulation in ALS (Q34103782)

31 July 2017

1 reference

title

Mitochondrial dysfunction and intracellular calcium dysregulation in ALS (English)

1 reference

amyotrophic lateral sclerosis

31 July 2017

main subject

1 reference

1

Hibiki Kawamata

1 reference

31 July 2017

Giovanni Manfredi

2

1 reference

31 July 2017

language of work or name

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20 May 2010

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Mechanisms of Ageing and Development

31 July 2017

published in

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31 July 2017

volume

131

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31 July 2017

issue

7-8

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31 July 2017

page(s)

517-526

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Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis

31 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

5 July 2018

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Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target?

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

5 July 2018

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5 July 2018

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5 July 2018

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Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

5 July 2018

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5 July 2018

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Mitochondria as biosensors of calcium microdomains

5 July 2018

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5 July 2018

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5 July 2018

1 reference

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Visualization of defective mitochondrial function in skeletal muscle fibers of patients with sporadic amyotrophic lateral sclerosis

5 July 2018

1 reference

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Mitochondrial transport of cations: channels, exchangers, and permeability transition.

5 July 2018

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5 July 2018

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Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells

5 July 2018

1 reference

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Excitotoxicity hypothesis

5 July 2018

1 reference

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

5 July 2018

1 reference

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Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis

5 July 2018

1 reference

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5 July 2018

1 reference

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Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

5 July 2018

1 reference

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Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis

5 July 2018

1 reference

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Brain glutamate deficiency in amyotrophic lateral sclerosis

5 July 2018

1 reference

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Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

5 July 2018

1 reference

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Dehydrogenase activation by Ca2+ in cells and tissues

5 July 2018

1 reference

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Reductions in acidic amino acids andN-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS

5 July 2018

1 reference

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The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms

5 July 2018

1 reference

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Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

The disulfide relay system of mitochondria is required for the biogenesis of mitochondrial Ccs1 and Sod1.

28 October 2018

1 reference

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Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria

28 October 2018

1 reference

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Mitochondrial changes in motor neurons of homozygotes of leucine 126 TT deletion SOD1 transgenic mice

28 October 2018

1 reference

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Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.

28 October 2018

1 reference

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AIF translocates to the nucleus in the spinal motor neurons in a mouse model of ALS.

28 October 2018

1 reference

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Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.

28 October 2018

1 reference

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Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Ca2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Up‐regulation of mitochondrial uncoupling protein 3 reveals an early muscular metabolic defect in amyotrophic lateral sclerosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Alteration in intracellular calcium homeostasis reduces motor neuronal viability expressing mutated Cu/Zn superoxide dismutase through a nitric oxide/guanylyl cyclase cGMP cascade

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Intrathecal cyclosporin prolongs survival of late-stage ALS mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

The role of reactive oxygen species in mitochondrial permeability transition

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933290

Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis

28 October 2018

1 reference

12 December 2020

Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

1 reference

12 December 2020

Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene

1 reference

12 December 2020

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS

1 reference

12 December 2020

Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Chromaffin-cell stimulation triggers fast millimolar mitochondrial Ca2+ transients that modulate secretion

1 reference

12 December 2020

Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations

1 reference

12 December 2020

Dendritic synapses of anterior horn neurons in amyotrophic lateral sclerosis: an ultrastructural study

1 reference

12 December 2020

Inhibition of ICE slows ALS in mice

1 reference

12 December 2020

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

1 reference

12 December 2020

Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function

1 reference

12 December 2020

Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

1 reference

12 December 2020

10.1016/J.MAD.2010.05.003

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference