Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers (Q34104555)

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5 February 2020

title

Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers (English)

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5 February 2020

13

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5 February 2020

author name string

Kathryn G Roberts

1

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5 February 2020

Amanda M Smith

2

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5 February 2020

Fiona McDougall

3

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5 February 2020

Helen Carpenter

4

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5 February 2020

Martin Horan

5

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5 February 2020

Paolo Neviani

6

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5 February 2020

Jason A Powell

7

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5 February 2020

Daniel Thomas

8

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5 February 2020

Mark A Guthridge

9

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5 February 2020

Danilo Perrotti

10

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5 February 2020

Alistair T R Sim

11

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Leonie K Ashman

12

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language of work or name

English

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publication date

15 June 2010

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5 February 2020

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5 February 2020

volume

70

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5 February 2020

issue

13

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5 February 2020

page(s)

5438-5447

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Genetic subgrouping of melanoma reveals new opportunities for targeted therapy

5 February 2020

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5 July 2018

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5 July 2018

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

5 July 2018

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Normal and oncogenic forms of the receptor tyrosine kinase kit.

5 July 2018

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Identification of specific PP2A complexes involved in human cell transformation

5 July 2018

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5 July 2018

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KIT mutations are common in testicular seminomas

5 July 2018

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Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells

5 July 2018

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

5 July 2018

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Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors

5 July 2018

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A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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28 October 2018

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28 October 2018

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Signal transduction by several KIT juxtamembrane domain mutations

28 October 2018

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Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.

28 October 2018

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Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

28 October 2018

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12 December 2020

Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes

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12 December 2020

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12 December 2020

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12 December 2020

Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity

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12 December 2020

Resistance to c-KIT kinase inhibitors conferred by V654A mutation

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12 December 2020

10.1158/0008-5472.CAN-09-2544

Identifiers

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