Early signaling pathways activated by c-Kit in hematopoietic cells (Q28139288)

International Journal of Biochemistry & Cell Biology

Europe PubMed Central

title

Early signaling pathways activated by c-Kit in hematopoietic cells (English)

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author name string

D Linnekin

series ordinal

1

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language of work or name

English

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publication date

October 1999

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published in

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volume

31

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issue

10

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page(s)

1053-74

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cites work

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W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

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Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis

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Steel mutant mice are deficient in hippocampal learning but not long-term potentiation

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The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

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Primary structure and functional expression of rat and human stem cell factor DNAs

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Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

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Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

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7 January 2021

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus

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The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

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The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

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A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

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Interspecies molecular chimeras of kit help define the binding site of the stem cell factor

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Structure-function analyses of the kit receptor for the steel factor

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The majority of stem cell factor exists as monomer under physiological conditions. Implications for dimerization mediating biological activity

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Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit

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Kit receptor dimerization is driven by bivalent binding of stem cell factor

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The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

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Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

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Role of dimerization of the membrane-associated growth factor kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis.

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The Dominant W 42 Spotting Phenotype Results from a Missense Mutation in the c- kit Receptor Kinase

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W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor

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7 January 2021

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

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Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

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Signalling through the lipid products of phosphoinositide-3-OH kinase

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

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A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

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Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

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Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase

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Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

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c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling

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The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

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Cytokine signal transduction and the JAK family of protein tyrosine kinases

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The Janus protein tyrosine kinases in hematopoietic cytokine signaling

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

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7 January 2021

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

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7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

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7 January 2021

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

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7 January 2021

Stem cell factor, the JAK-STAT pathway and signal transduction

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7 January 2021

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand

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7 January 2021

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

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7 January 2021

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

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7 January 2021

Cytokine receptor signalling

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STATs: signal transducers and activators of transcription

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7 January 2021

Stat1 associates with c-kit and is activated in response to stem cell factor

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7 January 2021

Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding

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7 January 2021

Distinct signaling from stem cell factor and erythropoietin in HCD57 cells

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7 January 2021

Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy

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7 January 2021

Cellular functions regulated by Src family kinases

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Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

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7 January 2021

Src family protein tyrosine kinases and cellular signal transduction pathways

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7 January 2021

Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

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7 January 2021

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes

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7 January 2021

The Src and Csk families of tyrosine protein kinases in hemopoietic cells.

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7 January 2021

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IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes.

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7 January 2021

The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e

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7 January 2021

The riddle of MAP kinase signaling specificity

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MAP kinases: charting the regulatory pathways

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Signal transduction via the MAP kinases: proceed at your own RSK.

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7 January 2021

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway

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7 January 2021

Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway

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7 January 2021

Multiple Cytokines Stimulate the Binding of a Common 145-Kilodalton Protein to Shc at the Grb2 Recognition Site of Shc

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7 January 2021

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

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7 January 2021

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

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7 January 2021

SHIP, a new player in cytokine-induced signalling

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7 January 2021

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

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7 January 2021

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

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7 January 2021

The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit

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7 January 2021

Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro

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7 January 2021

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

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7 January 2021

Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

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7 January 2021

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines

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7 January 2021

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL

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7 January 2021

Granulocyte-macrophage colony-stimulating factor and steel factor induce phosphorylation of both unique and overlapping signal transduction intermediates in a human factor-dependent hematopoietic cell line

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7 January 2021

Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells

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7 January 2021

Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells

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7 January 2021

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

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7 January 2021

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

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7 January 2021

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1

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7 January 2021

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

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7 January 2021

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

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7 January 2021

Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

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7 January 2021

Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.

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7 January 2021

PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals.

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7 January 2021

Stem cell factor induces phosphorylation of a 200 kDa protein which associates with c-kit

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7 January 2021

Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin

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7 January 2021

Interaction of the erythropoietin and stem-cell-factor receptors

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7 January 2021

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

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7 January 2021

Analysis of synergism between stem cell factor and granulocyte-macrophage colony-stimulating factor on human megakaryoblastic cells: an increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination

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7 January 2021

10.1016/S1357-2725(99)00078-3

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

4193359

4193359

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference