Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis (Q34112184)

31 July 2017

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title

Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis (English)

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31 July 2017

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4

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31 July 2017

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Xiongwei Zhu

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31 July 2017

7

Mark A Smith

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31 July 2017

3

Hyoung-gon Lee

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Siddhartha Mondragón-Rodríguez

31 July 2017

series ordinal

1

object named as

Siddhartha Mondragón-Rodríguez

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31 July 2017

Gustavo Basurto-Islas

series ordinal

2

object named as

Gustavo Basurto-Islas

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31 July 2017

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Rudy J Castellani

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31 July 2017

publication date

1 May 2010

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

31 July 2017

published in

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31 July 2017

volume

10

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31 July 2017

issue

5

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31 July 2017

page(s)

683-691

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RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission

31 July 2017

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Abeta(31-35)-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway

28 July 2018

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28 July 2018

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Differential Expression of Redox Factor-1 Associated with Beta-Amyloid-Mediated Neurotoxicity

28 July 2018

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Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity

28 July 2018

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Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches

28 July 2018

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DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.

28 July 2018

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Promising strategies for the prevention of dementia

28 July 2018

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Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging.

28 July 2018

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Genetics of Alzheimer's disease: recent advances

28 July 2018

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

28 July 2018

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A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

28 July 2018

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Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism

28 July 2018

1 reference

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Watching the watcher: regulation of p53 by mitochondria

28 July 2018

1 reference

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

28 July 2018

1 reference

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New age of neuroproteomics in Alzheimer's disease research

28 July 2018

1 reference

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Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update

28 July 2018

1 reference

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The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

28 July 2018

1 reference

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Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Truncation of tau protein and its pathological significance in Alzheimer's disease.

28 July 2018

1 reference

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Molecular genetics of Alzheimer's disease: an update

28 July 2018

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Differential incorporation of tau isoforms in Alzheimer's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Oxidative RNA damage and neurodegeneration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

28 July 2018

1 reference

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From tangles to tau protein.

28 July 2018

1 reference

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The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Tau phosphorylation and aggregation in Alzheimer's disease pathology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Cellular stress and nucleolar function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

The cell cycle in Alzheimer disease: a unique target for neuropharmacology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease

28 July 2018

1 reference

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Genetic aspects of Alzheimer's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Perspectives on the amyloid-beta cascade hypothesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Cerebrometabolic abnormalities in Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Cell cycle events in neurons. Proliferation or death?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Presenilin is required for activity and nuclear access of Notch in Drosophila

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Alz-50 antibody recognizes Alzheimer-related neuronal changes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Immunohistochemical evidence for the derivation of a peptide ligand from the amyloid beta-protein precursor of Alzheimer disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Abnormal brain glucose metabolism in Alzheimer's disease, as measured by position emission tomography

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Neuropathological stageing of Alzheimer-related changes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Epigenetics, oxidative stress, and Alzheimer disease

28 July 2018

1 reference

Cerebral blood flow and metabolic abnormalities in Alzheimer's disease

21 January 2018

1 reference

Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress

21 January 2018

1 reference

Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease

21 January 2018

1 reference

Oxidatively modified RNA in mild cognitive impairment

21 January 2018

1 reference

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

The apolipoprotein E epsilon4 allele and incident Alzheimer's disease in persons with mild cognitive impairment.

21 January 2018

1 reference

Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases.

21 January 2018

1 reference

APOE promoter polymorphisms do not confer independent risk for Alzheimer's disease in a French population.

21 January 2018

1 reference

Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk

21 January 2018

1 reference

Early-onset Alzheimer disease in an Italian family with presenilin-1 double mutation E318G and G394V.

21 January 2018

1 reference

A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment.

21 January 2018

1 reference

Presenilin 1 polymorphism associated with Alzheimer's disease in apolipoprotein E4 carriers.

21 January 2018

1 reference

A single mutation at the sheet switch region results in conformational changes favoring lambda6 light-chain fibrillogenesis

21 January 2018

1 reference

Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein.

21 January 2018

1 reference

Covariate analysis of late-onset Alzheimer disease refines the chromosome 12 locus.

21 January 2018

1 reference

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

21 January 2018

1 reference

Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease.

21 January 2018

1 reference

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons

21 January 2018

1 reference

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

21 January 2018

1 reference

Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder

21 January 2018

1 reference

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

1 reference

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

21 January 2018

1 reference

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

21 January 2018

1 reference

Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation

21 January 2018

1 reference

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

21 January 2018

1 reference

Conformational transition state is responsible for assembly of microtubule-binding domain of tau protein

21 January 2018

1 reference

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

1 reference

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease

21 January 2018

1 reference

Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.

21 January 2018

1 reference

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

21 January 2018

1 reference

Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells

21 January 2018

1 reference

Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease

21 January 2018

1 reference

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

21 January 2018

1 reference

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis

21 January 2018

1 reference

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

21 January 2018

1 reference

Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta

21 January 2018

1 reference

Alternative Abeta immunotherapy approaches for Alzheimer's disease

21 January 2018

1 reference

Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses

21 January 2018

1 reference

[The genetics of dementias. Part 1: Molecular basis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)].

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

CSF studies facilitate DNA diagnosis in familial Alzheimer's disease due to a presenilin-1 mutation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

AbetaPP A713T mutation in late onset Alzheimer's disease with cerebrovascular lesions.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Oxidative damage is the earliest event in Alzheimer disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Oxidative alterations in Alzheimer's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Increased nuclear DNA oxidation in the brain in Alzheimer's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922904

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

28 October 2018

1 reference

Neuronal cell cycle re-entry mediates Alzheimer disease-type changes

21 January 2018

1 reference

12 December 2020

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

12 December 2020

Effects of cholinesterase inhibitors and clonidine coadministration on rat cortex neurotransmitters in vivo

1 reference

12 December 2020

Distribution of beta amyloid associated proteins in plaques in Alzheimer's disease and in the non-demented elderly

1 reference

12 December 2020

Activation of oncogenic pathways in degenerating neurons in Alzheimer disease

1 reference

12 December 2020

Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland

1 reference

12 December 2020

Abeta, tau and ApoE4 in Alzheimer's disease: the axonal connection

1 reference

12 December 2020

1 reference

12 December 2020

Apoptosis and Alzheimer's Disease

1 reference

12 December 2020

Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1 reference

12 December 2020

Identifiers

DOI

10.1586/ERN.10.27

1 reference

31 July 2017

1 reference

31 July 2017

1 reference