Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration (Q34116399)

31 July 2017

1 reference

title

Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration (English)

1 reference

31 July 2017

1 reference

Ignacio R Rodríguez

1

1 reference

PubMed ID

20567027

31 July 2017

Ignacio M Larrayoz

series ordinal

2

1 reference

31 July 2017

21 June 2010

1 reference

Journal of Lipid Research

31 July 2017

1 reference

31 July 2017

51

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31 July 2017

10

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31 July 2017

2847-2862

1 reference

7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation

31 July 2017

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Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

5 July 2018

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5 July 2018

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Anti-VEGF agents for age-related macular degeneration

5 July 2018

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Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation

5 July 2018

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Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol

5 July 2018

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5 July 2018

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VEGF secretion by macrophages is stimulated by lipid and protein components of OxLDL via PI3-kinase and PKCzeta activation and is independent of OxLDL uptake

5 July 2018

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5 July 2018

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7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells

5 July 2018

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HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis

5 July 2018

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5 July 2018

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Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

5 July 2018

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Mitochondria and cellular oxygen sensing in the HIF pathway.

5 July 2018

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Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor

5 July 2018

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20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells

5 July 2018

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Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling.

5 July 2018

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High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1

5 July 2018

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Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

5 July 2018

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Oxysterols are substrates for cholesterol sulfotransferase

5 July 2018

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Enzymes in the conversion of cholesterol into bile acids.

5 July 2018

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New molecular histopathologic insights into the pathogenesis of age-related macular degeneration

5 July 2018

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Oxysterols in biological systems: sources, metabolism and pathophysiological relevance

5 July 2018

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Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

5 July 2018

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Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors

5 July 2018

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Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process

5 July 2018

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Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization

5 July 2018

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Toll-like receptor 4 signalling is neither sufficient nor required for oxidised phospholipid mediated induction of interleukin-8 expression

5 July 2018

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Membrane and protein interactions of oxysterols

5 July 2018

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High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture

5 July 2018

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Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification

5 July 2018

1 reference

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Oxysterol-induced toxicity in R28 and ARPE-19 cells

5 July 2018

1 reference

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Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor

5 July 2018

1 reference

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Quick-freeze/deep-etch visualization of age-related lipid accumulation in Bruch's membrane

5 July 2018

1 reference

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Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye

5 July 2018

1 reference

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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy

5 July 2018

1 reference

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Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids.

5 July 2018

1 reference

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Oxidized lipoproteins and macrophages

5 July 2018

1 reference

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A role for local inflammation in the formation of drusen in the aging eye.

5 July 2018

1 reference

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7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells

5 July 2018

1 reference

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Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis

5 July 2018

1 reference

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Oxysterol-binding-protein (OSBP)-related protein 4 binds25-hydroxycholesterol and interacts with vimentin intermediate filaments

5 July 2018

1 reference

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A family of 12 human genes containing oxysterol-binding domains

5 July 2018

1 reference

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7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells

5 July 2018

1 reference

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5 July 2018

1 reference

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Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells

5 July 2018

1 reference

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Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina

5 July 2018

1 reference

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7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta

5 July 2018

1 reference

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Studies of all-trans-retinal as a photooxidizing agent

5 July 2018

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Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

5 July 2018

1 reference

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5 July 2018

1 reference

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Accumulation of cholesterol with age in human Bruch's membrane.

5 July 2018

1 reference

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Cytotoxic effect of oxidized low density lipoprotein on macrophages

5 July 2018

1 reference

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Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

5 July 2018

1 reference

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Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1

5 July 2018

1 reference

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5 July 2018

1 reference

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

5 July 2018

1 reference

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cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

5 July 2018

1 reference

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Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions

5 July 2018

1 reference

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Localization of lipoprotein-delivered benzoporphyrin derivative in the rabbit eye.

5 July 2018

1 reference

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Review of progress in sterol oxidations: 1987-1995.

5 July 2018

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Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages

5 July 2018

1 reference

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Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin

5 July 2018

1 reference

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Chemistry and metabolism of lipids in the vertebrate retina

5 July 2018

1 reference

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Sterol metabolism. XXIII. Cholesterol oxidation by radiation-induced processes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol

5 July 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Comparison of the aerobic photoreactivity of A2E with its precursor retinal

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Iron release analyses from ferritin by visible light irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

The potential of fluorescent and spin-labeled steroid analogs to mimic natural cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Cerebrotendinous xanthomatosis: heterogeneity of clinical phenotype with evidence of previously undescribed ophthalmological findings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Interaction of caveolin with 7-ketocholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Toxicity of cholesterol oxides on cultured neuroretinal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Vascular endothelial growth factor in allergen-induced nasal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Phosphocholine as a pattern recognition ligand for CD36.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Mutation analysis of oxisterol-binding-protein gene in patients with age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.R004820

Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Time course of oxysterol formation during in vitro oxidation of low density lipoprotein

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936760

Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol

9 December 2018

1 reference

12 December 2020

Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina

1 reference

12 December 2020

Age related macular degeneration

1 reference

12 December 2020

[Lipid metabolism in retinal pigment epithelium. Possible significance of lipoprotein receptors]

1 reference

12 December 2020

Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols

1 reference

12 December 2020

In the presence of ferritin, visible light induces lipid peroxidation of the porcine photoreceptor outer segment

1 reference

12 December 2020

25-Hydroxycholesterol, 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages

1 reference

12 December 2020

Oxysterols Induced Inflammation and Oxidation in Primary Porcine Retinal Pigment Epithelial Cells

1 reference

12 December 2020

Oxysterol binding protein

1 reference

12 December 2020

Singlet oxygen intermediacy in the photodynamic action of membrane-bound hematoporphyrin derivative

1 reference

12 December 2020

Retinal pigment epithelium possesses both LDL and scavenger receptor activity

1 reference

12 December 2020

Photoperoxidation of cholesterol in homogeneous solution, isolated membranes, and cells: comparison of the 5 alpha- and 6 beta-hydroperoxides as indicators of singlet oxygen intermediacy

1 reference

12 December 2020

Transport of 22:6n-3 in the plasma and uptake into retinal pigment epithelium and retina

1 reference

12 December 2020

In vivo biosynthesis of cholesterol in the rat retina.

1 reference

12 December 2020

Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity

1 reference

12 December 2020

Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages

1 reference

12 December 2020

Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells

1 reference

12 December 2020

Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production

1 reference

12 December 2020

Cholesterol-metabolizing cytochromes P450: implications for cholesterol lowering

1 reference

12 December 2020

Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.R004820

1 reference

31 July 2017

1 reference

31 July 2017

1 reference

PubMed ID

20567027