Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold. (Q34128200)

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8 February 2020

title

Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold (English)

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8 February 2020

1 reference

3

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8 February 2020

Chavdar Krachmarov

5

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8 February 2020

Miroslaw K Gorny

11

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8 February 2020

Shan Lu

13

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8 February 2020

author name string

Maxim Totrov

1

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8 February 2020

Xunqing Jiang

2

1 reference

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8 February 2020

Sandra Cohen

4

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8 February 2020

Aidy Salomon

6

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8 February 2020

Constance Williams

7

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8 February 2020

Michael S Seaman

8

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8 February 2020

Timothy Cardozo

10

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8 February 2020

Shixia Wang

12

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8 February 2020

Abraham Pinter

14

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8 February 2020

Susan Zolla-Pazner

15

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8 February 2020

Ruben Abagyan

9

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8 February 2020

language of work or name

English

0 references

publication date

21 July 2010

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8 February 2020

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8 February 2020

volume

405

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8 February 2020

page(s)

513-523

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8 February 2020

issue

2

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Conserved structural elements in the V3 crown of HIV-1 gp120

8 February 2020

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Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens

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The use of immune complex vaccines to enhance antibody responses against neutralizing epitopes on HIV-1 envelope gp120.

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Viral sequence diversity: challenges for AIDS vaccine designs

5 July 2018

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5 July 2018

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Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity

5 July 2018

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Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses

5 July 2018

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Molecular architecture of native HIV-1 gp120 trimers

5 July 2018

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Structure determination of an anti-HIV-1 Fab 447-52D–peptide complex from an epitaxially twinned data set

5 July 2018

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Structure of Antibody F425-B4e8 in Complex with a V3 Peptide Reveals a New Binding Mode for HIV-1 Neutralization

5 July 2018

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Effectiveness in prevention of travellers' diarrhoea by an oral cholera vaccine WC/rBS.

5 July 2018

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Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

5 July 2018

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Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens

5 July 2018

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Analysis of the neutralization breadth of the anti-V3 antibody F425-B4e8 and re-assessment of its epitope fine specificity by scanning mutagenesis

5 July 2018

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Structural basis for coreceptor selectivity by the HIV type 1 V3 loop

5 July 2018

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Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy

5 July 2018

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Clinical experience with plasmid DNA- and modified vaccinia virus Ankara-vectored human immunodeficiency virus type 1 clade A vaccine focusing on T-cell induction

5 July 2018

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Type-specific epitopes targeted by monoclonal antibodies with exceptionally potent neutralizing activities for selected strains of human immunodeficiency virus type 1 map to a common region of the V2 domain of gp120 and differ only at single positio

5 July 2018

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Factors determining the breadth and potency of neutralization by V3-specific human monoclonal antibodies derived from subjects infected with clade A or clade B strains of human immunodeficiency virus type 1

5 July 2018

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Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1.

5 July 2018

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Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity

5 July 2018

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Improving on nature: focusing the immune response on the V3 loop.

5 July 2018

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5 July 2018

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Structure of a V3-containing HIV-1 gp120 core

5 July 2018

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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

5 July 2018

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The design and implementation of the immune epitope database and analysis resource

5 July 2018

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Antibodies that are cross-reactive for human immunodeficiency virus type 1 clade a and clade B v3 domains are common in patient sera from Cameroon, but their neutralization activity is usually restricted by epitope masking

5 July 2018

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Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

5 July 2018

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Different immune response of mice immunized with conjugates containing multiple copies of either consensus or mixotope versions of the V3 loop peptide from human immunodeficiency virus type 1.

5 July 2018

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Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope

5 July 2018

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The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.

5 July 2018

1 reference

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Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D

5 July 2018

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Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development

5 July 2018

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Antibody neutralization and escape by HIV-1

5 July 2018

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Alternative conformations of HIV-1 V3 loops mimic beta hairpins in chemokines, suggesting a mechanism for coreceptor selectivity

5 July 2018

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

5 July 2018

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Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.

5 July 2018

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Effect of soluble CD4 on exposure of epitopes on primary, intact, native human immunodeficiency virus type 1 virions of different genetic clades

5 July 2018

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The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region

5 July 2018

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Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor.

5 July 2018

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Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

5 July 2018

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Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent costimulation of CD4(+) T cells

5 July 2018

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5 July 2018

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Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity.

5 July 2018

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Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor

5 July 2018

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Structural studies of receptor binding by cholera toxin mutants

5 July 2018

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Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design

5 July 2018

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A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

5 July 2018

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Core structure of gp41 from the HIV envelope glycoprotein

5 July 2018

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CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.

5 July 2018

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Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus.

5 July 2018

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Envelope-binding domain in the cationic amino acid transporter determines the host range of ecotropic murine retroviruses.

5 July 2018

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Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

5 July 2018

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Immunological characterization of a rotavirus-neutralizing epitope fused to the cholera toxin B subunit

5 July 2018

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An endogenously synthesized decamer peptide efficiently primes cytotoxic T cells specific for the HIV-1 envelope glycoprotein.

5 July 2018

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The three-dimensional crystal structure of cholera toxin

5 July 2018

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Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS.

5 July 2018

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Presentation of native epitopes in the V1/V2 and V3 regions of human immunodeficiency virus type 1 gp120 by fusion glycoproteins containing isolated gp120 domains

5 July 2018

1 reference

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Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein

5 July 2018

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Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

5 July 2018

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Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein

5 July 2018

1 reference

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Small amino acid changes in the V3 hypervariable region of gp120 can affect the T-cell-line and macrophage tropism of human immunodeficiency virus type 1

5 July 2018

1 reference

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Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR(649-684), a mucosal subunit HIV/AIDS vaccine candidate.

5 July 2018

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Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.

28 October 2018

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Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2942080

A comparative study of different presentation strategies for an HIV peptide immunogen.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2942080

V3-specific polyclonal antibodies affinity purified from sera of infected humans effectively neutralize primary isolates of human immunodeficiency virus type 1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2942080

Characterization of an internal permissive site in the cholera toxin B-subunit and insertion of epitopes from human immunodeficiency virus-1, hepatitis B virus and enterotoxigenic Escherichia coli

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2942080

Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2942080

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2942080

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

28 October 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2010.06.027

Intranasal immunization using the B subunit of the Escherichia coli heat-labile toxin fused to an epitope of the Bordetella pertussis P.69 antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2010.06.027

HIV-1 antibody--debris or virion?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2010.06.027

Focusing the immune response on the V3 loop, a neutralizing epitope of the HIV-1 gp120 envelope

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2010.06.027

The cross-clade neutralizing activity of a human monoclonal antibody is determined by the GPGR V3 motif of HIV type 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2010.06.027

Candidate HIV/AIDS vaccines: lessons learned from the World's first phase III efficacy trials

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663531

12 December 2020

inferred from PubMed ID database lookup

Cholera toxin B subunit as a carrier protein to stimulate a mucosal immune response

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663531

12 December 2020

inferred from PubMed ID database lookup

Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20663531

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.VIROL.2010.06.027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663531%20AND%20SRC:MED&resulttype=core&format=json

release_y5zxnmy77ndjzm5f2wfmlpmlmm

8 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y5zxnmy77ndjzm5f2wfmlpmlmm

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20663531%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference