Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1 (Q34132738)

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English	Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1	scientific article

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20 January 2020

Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1 (English)

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20 January 2020

virtual screening

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based on heuristic

inferred from title

Edurne Gallastegui

1

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20 January 2020

Carmen Alvarez-Fernández

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Brett Marshall

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20 January 2020

Gonzalo Sanchez-Duffhues

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Juan A Collado

5

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Neus Luque

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20 January 2020

Jean-Michel Terme

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Josep M Gatell

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20 January 2020

Sonsoles Sánchez-Palomino

10

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18 January 2012

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20 January 2020

Journal of Virology

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20 January 2020

3795-3808

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20 January 2020

T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway

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5 July 2018

Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.

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5 July 2018

High-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.

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5 July 2018

Broadly cross-neutralizing antibodies in HIV-1 patients with undetectable viremia

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5 July 2018

Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency

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5 July 2018

NF-κB/Rel: agonist and antagonist roles in HIV-1 latency

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5 July 2018

Modulation of CD4+ T-cell activation by CD95 co-stimulation

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5 July 2018

HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals

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5 July 2018

Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines.

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5 July 2018

Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction

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5 July 2018

In silico directed chemical probing of the adenosine receptor family

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5 July 2018

Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

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5 July 2018

The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro

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5 July 2018

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

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5 July 2018

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

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5 July 2018

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

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5 July 2018

CpG methylation controls reactivation of HIV from latency

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5 July 2018

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells.

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5 July 2018

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection

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5 July 2018

Epigenetic regulation of HIV-1 latency by cytosine methylation

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5 July 2018

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

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5 July 2018

Transcriptional competence of the integrated HIV-1 provirus at the nuclear periphery

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5 July 2018

Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid

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5 July 2018

Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells

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5 July 2018

Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene

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5 July 2018

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

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5 July 2018

Transcriptional interference antagonizes proviral gene expression to promote HIV latency

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5 July 2018

Factors controlling chromatin organization and nucleosome positioning for establishment and maintenance of HIV latency

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5 July 2018

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.

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5 July 2018

HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription

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5 July 2018

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

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5 July 2018

In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling

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5 July 2018

Chromatin-associated regulation of HIV-1 transcription: implications for the development of therapeutic strategies

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5 July 2018

Isolation of new phenylacetylingol derivatives that reactivate HIV-1 latency and a novel spirotriterpenoid from Euphorbia officinarum latex

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5 July 2018

Primary cell model for activation-inducible human immunodeficiency virus

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5 July 2018

Sustained induction of NF-kappa B is required for efficient expression of latent human immunodeficiency virus type 1.

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5 July 2018

Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency

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5 July 2018

Controlling the elongation phase of transcription with P-TEFb

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5 July 2018

NF-kappaB activation by reactive oxygen species: fifteen years later

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5 July 2018

NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

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5 July 2018

Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli

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5 July 2018

Molecular mechanisms of HIV-1 proviral latency

1 reference

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5 July 2018

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

1 reference

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5 July 2018

Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription.

1 reference

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5 July 2018

IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART.

1 reference

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5 July 2018

The multifactorial nature of HIV-1 latency

1 reference

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5 July 2018

Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression

1 reference

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5 July 2018

Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes

1 reference

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5 July 2018

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter

1 reference

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5 July 2018

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells

1 reference

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5 July 2018

Molecular Characterization, Reactivation, and Depletion of Latent HIV

1 reference

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5 July 2018

HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.

1 reference

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5 July 2018

Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation

1 reference

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5 July 2018

The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

1 reference

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5 July 2018

1 reference

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5 July 2018

Latent reservoirs of HIV: obstacles to the eradication of virus

1 reference

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5 July 2018

Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.

1 reference

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5 July 2018

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

1 reference

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5 July 2018

Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines

1 reference

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5 July 2018

Transcriptional interference perturbs the binding of Sp1 to the HIV-1 promoter.

1 reference

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5 July 2018

Mutations in the tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line

1 reference

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5 July 2018

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

1 reference

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5 July 2018

A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency

1 reference

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5 July 2018

Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation.

1 reference

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5 July 2018

Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation.

1 reference

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5 July 2018

Ultraviolet irradiation and cytokines as regulators of HIV latency and expression

1 reference

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5 July 2018

Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist

1 reference

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5 July 2018

Induction of expression of human immunodeficiency virus in a chronically infected promonocytic cell line by ultraviolet irradiation

1 reference

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5 July 2018

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

1 reference

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5 July 2018

Bryostatin-1 synergizes with histone deacetylase inhibitors to reactivate HIV-1 from latency.

1 reference

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28 October 2018

Novel histone deacetylase inhibitors CG05 and CG06 effectively reactivate latently infected HIV-1.

1 reference

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28 October 2018

An in vitro system to model the establishment and reactivation of HIV-1 latency.

1 reference

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28 October 2018

Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir

1 reference

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28 October 2018

Stability of the latent reservoir for HIV-1 in patients receiving valproic acid

1 reference

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28 October 2018

Prostratin antagonizes HIV latency by activating NF-kappaB.

1 reference

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28 October 2018

Interleukin-7 induces HIV type 1 outgrowth from peripheral resting CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302487

28 October 2018

Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302487

28 October 2018

Generation of HIV latency during thymopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302487

28 October 2018

Reduction of the HIV-1-infected T-cell reservoir by immune activation treatment is dose-dependent and restricted by the potency of antiretroviral drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302487

28 October 2018

SHED: Shannon Entropy Descriptors from Topological Feature Distributions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302487

9 December 2018

Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22258251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-based approaches to in silico pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22258251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by Daxx

1 reference

https://pubmed.ncbi.nlm.nih.gov/22258251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22258251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.05972-11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22258251%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22258251%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22258251%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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