Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis (Q34132791)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20732909%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis (English)

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11 February 2020

1 reference

1

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11 February 2020

4

Markus F Neurath

1 reference

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11 February 2020

author name string

Georg Nagel

2

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11 February 2020

Leonid Eshkind

3

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11 February 2020

Leona D Samson

5

1 reference

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11 February 2020

Bernd Kaina

6

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11 February 2020

language of work or name

English

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publication date

23 August 2010

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11 February 2020

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11 February 2020

volume

31

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11 February 2020

issue

12

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11 February 2020

page(s)

2111-2117

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An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals

11 February 2020

cites work

1 reference

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Temozolomide in malignant gliomas: current use and future targets

5 July 2018

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Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice

5 July 2018

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O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo

5 July 2018

1 reference

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Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

5 July 2018

1 reference

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DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

5 July 2018

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Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence

5 July 2018

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MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

5 July 2018

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Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues

5 July 2018

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Chemically induced mouse models of intestinal inflammation

5 July 2018

1 reference

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Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years?

5 July 2018

1 reference

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The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

5 July 2018

1 reference

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Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat

5 July 2018

1 reference

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Total N-nitroso compounds and their precursors in hot dogs and in the gastrointestinal tract and feces of rats and mice: possible etiologic agents for colon cancer

5 July 2018

1 reference

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Base excision repair in nuclear and mitochondrial DNA.

5 July 2018

1 reference

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Meat consumption and colorectal cancer: a review of epidemiologic evidence

5 July 2018

1 reference

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Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

5 July 2018

1 reference

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DNA adduct formation from tobacco-specific N-nitrosamines

5 July 2018

1 reference

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Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: correlation between chromosomal damage and conversion ('stage I of tumor promotion') in vivo

5 July 2018

1 reference

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Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases

5 July 2018

1 reference

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Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.

5 July 2018

1 reference

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Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction

5 July 2018

1 reference

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Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer.

5 July 2018

1 reference

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Function of domains of human O6-alkylguanine-DNA alkyltransferase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

DNA repair protein MGMT protects against N-methyl-N-nitrosourea-induced conversion of benign into malignant tumors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2994278

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

28 October 2018

1 reference

12 December 2020

Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair

1 reference

12 December 2020

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1 reference

12 December 2020

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1 reference

12 December 2020

Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis

1 reference

12 December 2020

Epithelial NEMO links innate immunity to chronic intestinal inflammation

1 reference

12 December 2020

1 reference

12 December 2020

Base Excision Repair and its Role in Maintaining Genome Stability

1 reference

12 December 2020

The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea

1 reference

12 December 2020

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1 reference

12 December 2020

O6-alkylguanine DNA lesions trigger apoptosis

1 reference

12 December 2020

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

1 reference

12 December 2020

Identifiers

DOI

10.1093/CARCIN/BGQ174

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20732909%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20732909%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

20732909

1 reference