Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins (Q36570190)

15 August 2017

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins (English)

1 reference

15 August 2017

J M Bugni

1

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15 August 2017

L B Meira

series ordinal

2

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15 August 2017

L D Samson

series ordinal

3

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15 August 2017

language of work or name

English

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publication date

24 November 2008

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15 August 2017

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15 August 2017

28

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15 August 2017

5

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15 August 2017

734-741

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https://scigraph.springernature.com/pub.10.1038/onc.2008.426

15 August 2017

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cites work

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The multifaceted mismatch-repair system

30 September 2017

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Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer

30 September 2017

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A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

30 September 2017

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Mismatch repair and DNA damage signalling

30 September 2017

1 reference

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DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling

30 September 2017

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Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

30 September 2017

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Intestinal adenomas can develop with a stable karyotype and stable microsatellites

30 September 2017

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Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase

30 September 2017

1 reference

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Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors

30 September 2017

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The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis

30 September 2017

1 reference

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A gene hypermethylation profile of human cancer

30 September 2017

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In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine

30 September 2017

1 reference

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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

30 September 2017

1 reference

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Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

30 September 2017

1 reference

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Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice

30 September 2017

1 reference

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DNA adduct formation from tobacco-specific N-nitrosamines

30 September 2017

1 reference

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557788

Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice

30 September 2017

1 reference

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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

30 September 2017

1 reference

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hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557788

MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis

30 September 2017

1 reference

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The multistep nature of cancer

30 September 2017

1 reference

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

30 September 2017

1 reference

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In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557788

Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication

30 September 2017

1 reference

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Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557788

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

30 September 2017

1 reference

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Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells.

30 September 2017

1 reference

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A simplified assay for O6-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues.

28 June 2018

1 reference

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Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions

28 June 2018

1 reference

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Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice.

28 June 2018

1 reference

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Function of domains of human O6-alkylguanine-DNA alkyltransferase

21 September 2018

1 reference

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Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.

21 September 2018

1 reference

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Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557788

Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.

21 September 2018

1 reference

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Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557788

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

21 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.426

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.426

Methylation-induced blocks to in vitro DNA replication

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.426

Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.426

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.426

A comparison of in vivo cell proliferation measurements in the intestine of mouse and man

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19029948

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.426

1 reference

15 August 2017

1 reference

15 August 2017

1 reference