CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery (Q34137733)

31 July 2017

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery (English)

1 reference

31 July 2017

1

Maxim N Artyomov

1 reference

31 July 2017

Mieszko Lis

2

1 reference

31 July 2017

Srinivas Devadas

series ordinal

3

1 reference

31 July 2017

Mark M Davis

series ordinal

4

1 reference

31 July 2017

Arup K Chakraborty

series ordinal

5

1 reference

31 July 2017

language of work or name

English

0 references

publication date

13 September 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

1 reference

31 July 2017

107

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31 July 2017

16916-16921

1 reference

31 July 2017

39

1 reference

Efficient stochastic simulation of reaction-diffusion processes via direct compilation

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Rule-based modeling of biochemical systems with BioNetGen

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Digital signaling and hysteresis characterize ras activation in lymphoid cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Stochastic reaction-diffusion simulation with MesoRD.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

CD4-independent T cells impair TCR triggering of CD4-dependent T cells: a putative mechanism for T cell affinity maturation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

The immunological synapse: a molecular machine controlling T cell activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

A therapeutic CD4 monoclonal antibody inhibits TCR-zeta chain phosphorylation, zeta-associated protein of 70-kDa Tyr319 phosphorylation, and TCR internalization in primary human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Altered proximal T-cell receptor signalling events in mouse CD4+ T cells in the presence of anti-CD4 monoclonal antibodies: evidence for reduced phosphorylation of Zap-70 and LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Exact stochastic simulation of coupled chemical reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Redox equilibrium in mucosal T cells tunes the intestinal TCR signaling threshold

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1010568107

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference