New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. (Q34139570)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861826%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view (English)

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14 February 2020

1

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14 February 2020

Laura Vicente-Vicente

3

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14 February 2020

author name string

Yaremi Quiros

2

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14 February 2020

Ana I Morales

4

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14 February 2020

Francisco J Lopez-Hernandez

5

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14 February 2020

language of work or name

English

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publication date

22 September 2010

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14 February 2020

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14 February 2020

volume

79

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14 February 2020

issue

1

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14 February 2020

page(s)

33-45

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https://scigraph.springernature.com/pub.10.1038/ki.2010.337

14 February 2020

exact match

0 references

cites work

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Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

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Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin

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Aminoglycoside-induced renal phospholipidosis and nephrotoxicity

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7 January 2021

Pathogenic factors in aminoglycoside-induced nephrotoxicity

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7 January 2021

Early effects of gentamicin, tobramycin, and amikacin on the human kidney

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7 January 2021

Incidence of and significant risk factors for aminoglycoside-associated nephrotoxicity in patients dosed by using individualized pharmacokinetic monitoring

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7 January 2021

Iron supplementation increases gentamicin nephrotoxicity in rats

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7 January 2021

Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients

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7 January 2021

Nephrotoxicity with gentamicin or tobramycin

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7 January 2021

Risk Factors for Nephrotoxicity in Patients Treated with Aminoglycosides

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7 January 2021

Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy

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7 January 2021

Once-daily dosing decreases renal accumulation of gentamicin and netilmicin

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7 January 2021

Quantitative nephrotoxicity of gentamicin in nontoxic doses

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7 January 2021

Comparative clinical study of tobramycin and gentamicin

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7 January 2021

Aminoglycosides: nephrotoxicity

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7 January 2021

Acute gentamicin-induced hypercalciuria and hypermagnesiuria in the rat: dose-response relationship and role of renal tubular injury

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https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues

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7 January 2021

Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats

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https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats

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https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides

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7 January 2021

A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer

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7 January 2021

Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Turning point in apoptosis/necrosis induced by hydrogen peroxide

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

"Simple but not simpler": toward a unified picture of energy requirements in cell death

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Hypoxia sensitizes human malignant glioma cells towards CD95L-induced cell death.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Light-microscopic immunocytochemistry for gentamicin and its use for studying uptake of the drug in kidney

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Autoradiography of gentamicin uptake by the rat proximal tubule cell

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Pathogenesis of nephrotoxicity of cephalosporins and aminoglycosides: a review of current concepts.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Tubular injury and regeneration in the rat kidney following acute exposure to gentamicin: a time-course study

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Molecular parameters involved in aminoglycoside nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effect of gentamicin on phospholipid metabolism in cultured rabbit proximal tubular cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Plasma lipid profile in rats with gentamicin-induced nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Nephrotoxicity of aminoglycoside antibiotics.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Drug-phospholipid interactions: role in aminoglycoside nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity

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https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Polyaspartic acid inhibits gentamicin-induced perturbations of phospholipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Studies on gentamicin-induced labilization of rat kidney lysosomes in vitro. Possible protection by selenium

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effect of gentamicin on the lysosomal system of cultured human proximal tubular cells. Endocytotic activity, lysosomal pH and membrane fragility

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Polycations induce the release of soluble intermembrane mitochondrial proteins.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

A role for superoxide in gentamicin-mediated nephropathy in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Proteases in renal cell death: calpains mediate cell death produced by diverse toxicants

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Cathepsin-regulated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Bid, a BH3-only multi-functional molecule, is at the cross road of life and death

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Cell death by necrosis: towards a molecular definition

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Characterization of gentamicin-induced dysfunctions in vitro: the use of optimized primary cultures of rabbit proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Calpain and caspase inhibitors protect vestibular sensory cells from gentamicin ototoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2)

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Aminoglycoside antibiotics alter the electrogenic transport properties of cultured human proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin inhibition of Na+,K(+)-ATPase in rat kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Dysregulation of renal sodium transporters in gentamicin-treated rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Quantitative correlation between cell swelling and necrosis in myocardial ischemia in dogs

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Role of tubular obstruction in acute renal failure due to gentamicin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densa

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Resetting protects efficiency of tubuloglomerular feedback.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Temporal adaptation of tubuloglomerular feedback: effects of COX-2.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Glomerular nephrotoxicity of aminoglycosides

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Pathophysiology of altered glomerular function in aminoglycoside-treated rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Role of platelet activating factor in gentamicin and cisplatin nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin induces Jun-AP1 expression and JNK activation in renal glomeruli and cultured mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Glomerular basement membrane alterations induced by gentamicin administration in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Renal ultrastructural and biochemical injuries induced by aminoglycosides

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effects of aminoglycosides on glomerular ultrastructure

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin activates rat mesangial cells. A role for platelet activating factor

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Increased renal glomerular endothelin-1 release in gentamicin-induced nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Renal effects of platelet-activating factor in the rat.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Potential role of platelet activating factor in acute renal failure.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Altered NMDA receptor expression in renal toxicity: Protection with a receptor antagonist

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Roles of hemodynamic and tubular factors in gentamicin-mediated nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Protective effect of trans-resveratrol on gentamicin-induced nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Reduction of renal blood flow and proximal bicarbonate reabsorption in rats by gentamicin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Physiological regulation of renal blood flow and glomerular filtration rate by the endothelium and smooth muscle

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Does gentamicin induce acute renal failure by increasing renal TXA2 synthesis in rats?

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Prostaglandins and aminoglycoside nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Nitric oxide and oxidative stress in vascular disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Protective effect of L-arginine intake on the impaired renal vascular responses in the gentamicin-treated rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

The mechanism by which aminoglycoside antibiotics cause vasodilation of canine cerebral arteries

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

The polycationic aminoglycosides modulate the vasoconstrictive effects of endothelin: relevance to cerebral vasospasm

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Evolution of morphologic changes after intravitreous injection of gentamicin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Morphological Changes and Alterations in Regional Intrarenal Blood Flow Induced by Graded Renal Ischemia

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Gentamicin nephrotoxicity in humans and animals: some recent research

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Increased renal susceptibility to gentamicin in the rat with obstructive jaundice. Role of lipid peroxidation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Protective effects of vitamin e and probucol against gentamicin-induced nephrotoxicity in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Involvement of reactive oxygen species on gentamicin-induced mesangial cell activation.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury?

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

The pathology of acute renal failure due to interstitial nephritis in man with comments on the role of interstitial inflammation and sex in gentamicin nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Plasma protein extravasation and vascular endothelial growth factor expression with endothelial nitric oxide synthase induction in gentamicin-induced acute renal failure in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effects of co-supplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Selective nuclear factor kappa-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Tissue-specific regulation of inflammation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

An integrative view on the role of TGF-beta in the progressive tubular deletion associated with chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Drug-associated renal dysfunction.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Acute renal failure in intensive care units--causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Effect of PEGylation of N-WASP181-200 on the inhibitory potency for renal aminoglycoside accumulation.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

The effect of verapamil on the nephrotoxic potential of gentamicin as measured by urinary enzyme excretion in healthy volunteers

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2010.337

7 January 2021

Identifiers

DOI

10.1038/KI.2010.337

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861826%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 February 2020

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1 reference