Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies (Q34152646)

31 July 2017

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title

Ubiquitin-dependent proteolysis: its role in human diseases and the design of therapeutic strategies (English)

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31 July 2017

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Kathleen M Sakamoto

1

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31 July 2017

publication date

1 September 2002

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Molecular Genetics and Metabolism

31 July 2017

published in

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31 July 2017

volume

77

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31 July 2017

issue

1-2

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31 July 2017

page(s)

44-56

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

31 July 2017

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7 January 2021

The 26S proteasome: a molecular machine designed for controlled proteolysis

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Mechanisms underlying ubiquitination

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

SCF and Cullin/Ring H2-based ubiquitin ligases

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

A proteasome howdunit: the case of the missing signal

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The U box is a modified RING finger — a common domain in ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Themes and variations on ubiquitylation

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Does this have a familiar RING?

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The F-box protein family.

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Functional analysis of FAR1 in yeast

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

VHL takes HIF's breath away

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Cullin 4A associates with the UV-damaged DNA-binding protein DDB

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Emerging roles of ubiquitin in transcription regulation

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The anaphase-promoting complex: proteolysis in mitosis and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The APC11 RING-H2 finger mediates E2-dependent ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The anaphase-promoting complex: new subunits and regulators

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The RING finger domain: a recent example of a sequence-structure family

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The PHD finger: implications for chromatin-mediated transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Modifying chromatin and concepts of cancer

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

β-catenin is a target for the ubiquitin–proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Mutations of the VHL tumour suppressor gene in renal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Cbl: many adaptations to regulate protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Beyond the RING: CBL proteins as multivalent adapters

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Regulatory functions of ubiquitination in the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

UBE3A/E6-AP mutations cause Angelman syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Neurochemical and neurogenetic correlates of Parkinson's disease.

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Parkin is linked to the ubiquitin pathway

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Degradation of alpha-synuclein by proteasome

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

1 reference

7 January 2021

Ubiquitin is a component of neurofibrillary tangles in a variety of neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Viral strategies of immune evasion

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Epstein-Barr virus: adaptation to a life within the immune system

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Synthesis and evaluation of geldanamycin-testosterone hybrids

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

Synthesis and evaluation of geldanamycin-estradiol hybrids

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https://api.crossref.org/works/10.1016%2FS1096-7192%2802%2900146-4

7 January 2021

10.1016/S1096-7192(02)00146-4

Identifiers

DOI

1 reference

31 July 2017

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