Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival (Q34152677)

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English	Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Li Chen

1

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Europe PubMed Central

PubMed publication ID

31 July 2017

Yanlin Ma

2

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31 July 2017

Eun Young Kim

3

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Europe PubMed Central

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31 July 2017

Wei Yu

4

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Europe PubMed Central

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31 July 2017

Robert J Schwartz

5

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31 July 2017

Ling Qian

6

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31 July 2017

Jun Wang

7

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31 July 2017

language of work or name

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publication date

1 February 2012

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Europe PubMed Central

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31 July 2017

7

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Europe PubMed Central

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31 July 2017

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

e31005

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Creative Commons Attribution 4.0 International

1 February 2012

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April 2022 Public Data File from Crossref

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0 references

Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.

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EZH2 depletion blocks the proliferation of colon cancer cells

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Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects

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5 July 2018

Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability

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5 July 2018

Epigenetic factors and cardiac development

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5 July 2018

Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?

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Defective sumoylation pathway directs congenital heart disease

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Aberrations of EZH2 in cancer

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5 July 2018

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

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5 July 2018

Chromatin remodeling in cardiovascular development and physiology

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Cardiac function and disease: emerging role of small ubiquitin-related modifier

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The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload

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5 July 2018

Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

The polycomb repressive complex 2 is a potential target of SUMO modifications

1 reference

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5 July 2018

Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier

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5 July 2018

Notch signaling in cardiac development

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5 July 2018

Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

The multifaceted role of Notch in cardiac development and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Epigenetic gene silencing in cancer: the DNA hypermethylome

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5 July 2018

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

1 reference

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5 July 2018

Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Hyperconserved CpG domains underlie Polycomb-binding sites

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5 July 2018

Polycomb recruitment to DNA in vivo by the YY1 REPO domain.

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5 July 2018

Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts

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5 July 2018

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

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5 July 2018

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Cell biology of cardiac cushion development.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Common congenital heart disorders in adults

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5 July 2018

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

A decade of discoveries in cardiac biology

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5 July 2018

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa

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5 July 2018

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

HES and HERP families: multiple effectors of the Notch signaling pathway

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3270034

5 July 2018

Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity

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5 July 2018

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

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5 July 2018

The polycomb-group gene Ezh2 is required for early mouse development

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5 July 2018

Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virus

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5 July 2018

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

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5 July 2018

Fate of the mammalian cardiac neural crest

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5 July 2018

Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis

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5 July 2018

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

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5 July 2018

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

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5 July 2018

Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031005

21 January 2018

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031005

21 January 2018

Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031005

21 January 2018

Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031005

21 January 2018

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells

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28 October 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031005

21 January 2018

The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22312437

12 December 2020

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10.1371/JOURNAL.PONE.0031005

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Europe PubMed Central

PubMed publication ID

31 July 2017

2012PLoSO...731005C

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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