The multifaceted role of Notch in cardiac development and disease (Q37028771)

17 August 2017

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title

The multifaceted role of Notch in cardiac development and disease (English)

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17 August 2017

Frances A High

1

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PubMed ID

18071321

17 August 2017

Jonathan A Epstein

series ordinal

2

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17 August 2017

1 January 2008

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17 August 2017

Nature Reviews Genetics

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17 August 2017

9

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17 August 2017

1

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17 August 2017

49-61

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https://scigraph.springernature.com/pub.10.1038/nrg2279

17 August 2017

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cites work

Notch signalling: a simple pathway becomes complex

1 reference

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

31 March 2020

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

31 March 2020

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Mutations in NOTCH1 cause aortic valve disease

31 March 2020

1 reference

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

31 March 2020

1 reference

Jagged1 mutations in patients ascertained with isolated congenital heart defects

31 March 2020

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Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

31 March 2020

1 reference

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

31 March 2020

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Dosage-sensitive requirement for mouse Dll4 in artery development

31 March 2020

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

31 March 2020

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Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

31 March 2020

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Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

31 March 2020

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Notch signaling in vascular development and physiology

31 March 2020

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Notch signaling in blood vessels: who is talking to whom about what?

31 March 2020

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Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling

31 March 2020

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Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development.

31 March 2020

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Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis

31 March 2020

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Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo.

31 March 2020

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Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division

31 March 2020

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Notch signaling plays a key role in cardiac cell differentiation

31 March 2020

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Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse

31 March 2020

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Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins

31 March 2020

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Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C

31 March 2020

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The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis

31 March 2020

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Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

31 March 2020

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Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development

31 March 2020

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Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2.

31 March 2020

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Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

31 March 2020

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Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

31 March 2020

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Molecular regulation of atrioventricular valvuloseptal morphogenesis

31 March 2020

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The snail superfamily of zinc-finger transcription factors

31 March 2020

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Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

31 March 2020

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Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation

31 March 2020

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Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve

31 March 2020

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Calcific aortic stenosis: from bench to the bedside--emerging clinical and cellular concepts

31 March 2020

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Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4

31 March 2020

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Requirement for neuregulin receptor erbB2 in neural and cardiac development

31 March 2020

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Multiple essential functions of neuregulin in development

31 March 2020

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Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

31 March 2020

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BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

31 March 2020

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Notch signaling is essential for ventricular chamber development

31 March 2020

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Analysis of cardiovascular phenotype and genotype-phenotype correlation in individuals with a JAG1 mutation and/or Alagille syndrome

31 March 2020

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Presenilin 1 is essential for cardiac morphogenesis

31 March 2020

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Gamma-secretase: proteasome of the membrane?

31 March 2020

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31 March 2020

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Building the mammalian heart from two sources of myocardial cells

31 March 2020

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An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

31 March 2020

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Notch in the pathway: the roles of Notch signaling in neural crest development.

31 March 2020

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Vascular anomalies in Alagille syndrome: a significant cause of morbidity and mortality

31 March 2020

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Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway

31 March 2020

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Smooth Muscle alpha-actin is a direct target of Notch/CSL

31 March 2020

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Notch3 is required for arterial identity and maturation of vascular smooth muscle cells

31 March 2020

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HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box

31 March 2020

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Notch signaling represses myocardin-induced smooth muscle cell differentiation

31 March 2020

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HES and HERP families: multiple effectors of the Notch signaling pathway

31 March 2020

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HERP1 is a cell type-specific primary target of Notch

31 March 2020

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HERP, a new primary target of Notch regulated by ligand binding

31 March 2020

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Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling

31 March 2020

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Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system

31 March 2020

1 reference

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments

31 March 2020

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Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split

31 March 2020

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Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

31 March 2020

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Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis

31 March 2020

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Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

31 March 2020

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Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

31 March 2020

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31 March 2020

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Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

31 March 2020

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Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome

31 March 2020

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The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation

31 March 2020

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Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function

31 March 2020

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CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression

31 March 2020

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

31 March 2020

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Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

31 March 2020

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Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

31 March 2020

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Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

31 March 2020

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31 March 2020

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Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4

31 March 2020

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Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

31 March 2020

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Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation.

31 March 2020

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Crossing paths with Notch in the hyper-network

31 March 2020

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Pursuing cardiac progenitors: regeneration redux

31 March 2020

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Notch signaling in stem cell systems

31 March 2020

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The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.

31 March 2020

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RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells

31 March 2020

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Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants

31 March 2020

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The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis

31 March 2020

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Stem cell niches in the adult mouse heart

31 March 2020

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Heart regeneration in zebrafish

31 March 2020

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Activation of Notch signaling pathway precedes heart regeneration in zebrafish

31 March 2020

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Gene expression analysis of zebrafish heart regeneration

31 March 2020

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Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

31 March 2020

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Notch signaling: the demise of elegant simplicity

31 March 2020

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Notch1 is essential for postimplantation development in mice.

31 March 2020

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Maintenance of somite borders in mice requires the Delta homologue DII1.

31 March 2020

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The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries.

31 March 2020

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Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

31 March 2020

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Skeletal and CNS defects in Presenilin-1-deficient mice

31 March 2020

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

31 March 2020

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG2279

1 reference

17 August 2017

1 reference

PubMed ID

18071321