Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis (Q34169514)

31 July 2017

Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis (English)

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31 July 2017

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2

Wilhelm Schänzer

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31 July 2017

Mario Thevis

3

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31 July 2017

1

Simon Beuck

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31 July 2017

24 February 2012

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Drug Testing and Analysis

31 July 2017

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31 July 2017

4

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31 July 2017

11

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31 July 2017

830-845

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

31 July 2017

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Researches on fat metabolism. II.

21 January 2018

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Importance of hemoglobin concentration to exercise: acute manipulations

21 January 2018

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7 January 2021

Recent developments in doping testing for erythropoietin

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7 January 2021

Erythropoiesis-stimulating agents and other methods to enhance oxygen transport

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7 January 2021

Blood doping and its detection

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7 January 2021

Therapeutic manipulation of the HIF hydroxylases

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7 January 2021

Emerging drugs: mechanism of action, mass spectrometry and doping control analysis.

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7 January 2021

Purification and characterization of hypoxia-inducible factor 1

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7 January 2021

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

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7 January 2021

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

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7 January 2021

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

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7 January 2021

Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha

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7 January 2021

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

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7 January 2021

Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

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7 January 2021

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

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7 January 2021

Identification of the renal erythropoietin-producing cells using transgenic mice

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7 January 2021

HIF prolyl hydroxylase inhibitors for anemia

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7 January 2021

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

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7 January 2021

Hypoxia. 2. Hypoxia regulates cellular metabolism

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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7 January 2021

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

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7 January 2021

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

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7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

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7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

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7 January 2021

Experimental production of polycythemia in humans by administration of cobalt chloride

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7 January 2021

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

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7 January 2021

Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

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7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

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7 January 2021

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

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7 January 2021

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

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7 January 2021

Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance

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7 January 2021

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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7 January 2021

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

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7 January 2021

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors

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7 January 2021

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors

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7 January 2021

Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors

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7 January 2021

A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors

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7 January 2021

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

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7 January 2021

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

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7 January 2021

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

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7 January 2021

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.

1 reference

7 January 2021

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

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7 January 2021

Prophylactic use of NSAIDs by athletes: a risk/benefit assessment.

1 reference

7 January 2021

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

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7 January 2021

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

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7 January 2021

Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation

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7 January 2021

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

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7 January 2021

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

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7 January 2021

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

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7 January 2021

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

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7 January 2021

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

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7 January 2021

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

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7 January 2021

Mass spectrometric identification and characterization of a new long-term metabolite of metandienone in human urine.

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7 January 2021

Development of liquid chromatography-tandem mass spectrometry-based analytical assays for the determination of HIF stabilizers in preventive doping research

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7 January 2021

Unusual mass spectrometric dissociation pathway of protonated isoquinoline-3-carboxamides due to multiple reversible water adduct formation in the gas phase

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7 January 2021

Comprehensive plasma-screening for known and unknown substances in doping controls

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7 January 2021

Cobalt chloride administration in athletes: a new perspective in blood doping?

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7 January 2021

Erythropoiesis stimulating agents and techniques: a challenge for doping analysts

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7 January 2021

Blood doping by cobalt. Should we measure cobalt in athletes?

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7 January 2021

Determination of cobalt in urine by gas chromatography-mass spectrometry employing nickel as an internal standard

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7 January 2021

Application of electrospray ionization tandem mass spectrometry for the rapid and sensitive determination of cobalt in urine

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7 January 2021

The biological occurrence and trafficking of cobalt.

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7 January 2021

High-resolution ICP-MS determination of Ti, V, Cr, Co, Ni, and Mo in human blood and urine of patients implanted with a hip or knee prosthesis.

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7 January 2021

Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods

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7 January 2021

In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: involvement in oxidative stress

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7 January 2021

Toxic dose of a simple phenolic antioxidant, protocatechuic acid, attenuates the glutathione level in ICR mouse liver and kidney

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7 January 2021

Protocatechuic acid is the major human metabolite of cyanidin-glucosides.

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7 January 2021

Regulation of activity of the transcription factor GATA-1 by acetylation

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7 January 2021

A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA

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7 January 2021

A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA.

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7 January 2021

Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease

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7 January 2021

Does k-11706 enhance performance and why?

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7 January 2021

Lexicon of lipid nutrition (IUPAC Technical Report)

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7 January 2021

Increased vigabatrin entry into the brain by polysorbate 80 and sodium caprate.

1 reference

7 January 2021

Medium-chain-triglyceride lipid emulsion: metabolism and tissue distribution

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7 January 2021

Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil.

1 reference

7 January 2021

Effects of medium-chain triglyceride feeding on energy balance in adult humans

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7 January 2021

Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography

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7 January 2021

A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples

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7 January 2021

Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet

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7 January 2021

Identifiers

DOI

10.1002/DTA.390

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31 July 2017

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PubMed ID

22362605