Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. (Q34182665)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21543327%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide (English)

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30 January 2020

3

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4

Yusuf A Hannun

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30 January 2020

author name string

Mehrdad Rahmaniyan

series ordinal

1

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30 January 2020

Robert W Curley

series ordinal

2

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30 January 2020

Jacqueline M Kraveka

series ordinal

5

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30 January 2020

language of work or name

English

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publication date

4 May 2011

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Journal of Biological Chemistry

30 January 2020

published in

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30 January 2020

volume

286

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30 January 2020

issue

28

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30 January 2020

page(s)

24754-24764

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Dihydroceramide desaturase activity is modulated by oxidative stress.

30 January 2020

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Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas

28 July 2018

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N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

28 July 2018

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The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

28 July 2018

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Principles of bioactive lipid signalling: lessons from sphingolipids

28 July 2018

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Pharmacokinetics of oral fenretinide in neuroblastoma patients: indications for optimal dose and dosing schedule also with respect to the active metabolite 4-oxo-fenretinide

28 July 2018

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Synthetic retinoid fenretinide in breast cancer chemoprevention

28 July 2018

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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

28 July 2018

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Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs

28 July 2018

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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

28 July 2018

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Tailoring structure-function and targeting properties of ceramides by site-specific cationization

28 July 2018

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4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines

28 July 2018

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Dihydroceramide hinders ceramide channel formation: Implications on apoptosis

28 July 2018

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Preparation of intact microsomes from cultured mammalian H4IIE cells

28 July 2018

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gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

28 July 2018

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Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.

28 July 2018

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Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation

28 July 2018

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DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine

28 July 2018

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Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase

28 July 2018

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28 July 2018

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N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase

28 July 2018

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Dihydroceramide desaturase

28 July 2018

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Conversion of dihydroceramide into ceramide: involvement of a desaturase

28 July 2018

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Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide

28 July 2018

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The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis

28 July 2018

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28 July 2018

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Biologically active sphingolipids in cancer pathogenesis and treatment

28 July 2018

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Identification and characterization of a sphingolipid delta 4-desaturase family

21 January 2018

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The CLN9 protein, a regulator of dihydroceramide synthase.

21 January 2018

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Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons.

21 January 2018

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Irreversible inhibition of CYP2D6 by (-)-chloroephedrine, a possible impurity in methamphetamine.

21 January 2018

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Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children's Oncology Group (CCG 09709).

21 January 2018

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Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.

21 January 2018

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Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase

21 January 2018

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Mechanism of fenretinide (4-HPR)-induced cell death

21 January 2018

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Regulation of G1/S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4HPR)

28 October 2018

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12 December 2020

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

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12 December 2020

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide

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12 December 2020

Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase This work was supported by the Dirección General de Enseñanza Superior e Investigación Científica (grant PB97-1171) and the Departament d'Universitats

1 reference

12 December 2020

Fenretinide (4-HPR) in chemoprevention of oral leukoplakia

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12 December 2020

Identifiers

DOI

10.1074/JBC.M111.250779

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21543327%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21543327%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference