Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy (Q34185428)

31 July 2017

1 reference

title

Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy (English)

1 reference

31 July 2017

Yasuyo Suzuki

1

1 reference

31 July 2017

Ikuru Yazawa

series ordinal

2

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31 July 2017

publication date

25 April 2011

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International Journal of Clinical and Experimental Pathology

31 July 2017

published in

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31 July 2017

volume

4

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31 July 2017

issue

4

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31 July 2017

page(s)

378-384

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Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy.

31 July 2017

cites work

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Trinucleotide Repeat Disorders

5 July 2018

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5 July 2018

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Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

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5 July 2018

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5 July 2018

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Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

5 July 2018

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5 July 2018

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5 July 2018

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

5 July 2018

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Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

5 July 2018

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Glutamine repeats and neurodegeneration

5 July 2018

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Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

5 July 2018

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Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

5 July 2018

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Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Expanded glutamine repeat enhances complex formation of dentatorubral-pallidoluysian atrophy (DRPLA) protein in human brains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

5 July 2018

1 reference

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

5 July 2018

1 reference

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Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy

5 July 2018

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Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

5 July 2018

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

5 July 2018

1 reference

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

5 July 2018

1 reference

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Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p

5 July 2018

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The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family

5 July 2018

1 reference

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Abnormal gene product identified in hereditary dentatorubral–pallidoluysian atrophy (DRPLA) brain

5 July 2018

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Familial myoclonus epilepsy and choreoathetosis: hereditary dentatorubral-pallidoluysian atrophy

5 July 2018

1 reference

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Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Sharing of polyglutamine localization by the neuronal nucleus and cytoplasm in CAG-repeat diseases

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Abnormal dentatorubral-pallidoluysian atrophy (DRPLA) protein complex is pathologically ubiquitinated in DRPLA brains

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093063

Hereditary dentatorubral-pallidoluysian atrophy: Clinical and pathologic variants in a family

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21577324

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Anticipation in hereditary dentatorubral-pallidoluysian atrophy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21577324

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

PMC publication ID

3093063

1 reference

31 July 2017

1 reference