Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling (Q34196017)

reason for preferred rank

31 July 2017

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

1 January 2024

Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

ubiquitin-conjugating enzymes

1 January 2024

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

intracellular signaling peptides and proteins

1 January 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

1 January 2024

Xenopus proteins

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

1 January 2024

signal transduction

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

1 January 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

1 January 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

1 January 2024

author name string

Chenbei Chang

2

1 reference

31 July 2017

Dong Liu

3

1 reference

31 July 2017

Rik Derynck

4

1 reference

31 July 2017

Pierre S. W. Lee

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

1 January 2024

language of work or name

English

0 references

publication date

11 May 2003

1 reference

full work available at URL

31 July 2017

http://www.jbc.org/content/278/30/27853.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740389

https://api.elsevier.com/content/article/PII:S0021925820845116?httpAccept=text/xml

1 January 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

https://api.elsevier.com/content/article/PII:S0021925820845116?httpAccept=text/plain

1 January 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

https://syndication.highwire.org/content/doi/10.1074/jbc.M301755200

1 January 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

Journal of Biological Chemistry

1 January 2024

published in

1 reference

31 July 2017

278

1 reference

31 July 2017

30

1 reference

31 July 2017

27853-27863

1 reference

Signaling networks--do all roads lead to the same genes?

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Signaling through scaffold, anchoring, and adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Post-translational modification of proteins and the discovery of new medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Signal Transduction and the Control of Gene Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Ubiquitin-like proteins: new wines in new bottles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Transcription factor Sp3 is silenced through SUMO modification by PIAS1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

TGF-beta signaling in tumor suppression and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Signal transduction by the TGF-beta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Transforming growth factor-beta (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-beta receptor complex. Characterization of chimeric and truncated type I and type II receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Human Smad3 and Smad4 are sequence-specific transcription activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Signaling of transforming growth factor-beta family members through Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

SP-RING for SUMO: new functions bloom for a ubiquitin-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

SUMO-1: wrestling with a new ubiquitin-related modifier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

SUMO--nonclassical ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Characterization of functional domains within Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Regulation of Smad signalling by protein associations and signalling crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Smads: transcriptional activators of TGF-beta responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Role of Ras and Mapks in TGFbeta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Regulation of Smad signaling by protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Identification of three major sentrinization sites in PML

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Nuclear neighbours: the spatial and functional organization of genes and nuclear domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Functional architecture in the cell nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301755200

Protein modification by SUMO

21 January 2018

7

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

1 January 2024

63

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 January 2024

64

1 reference

https://api.crossref.org/works/10.1074/JBC.M301755200

1 January 2024

Identifiers

1 reference

31 July 2017

1 reference