Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms (Q34207699)

31 July 2017

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms (English)

1 reference

31 July 2017

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Pierre De Meyts

2

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author name string

Louise Knudsen

series ordinal

1

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PubMed ID

21838706

31 July 2017

Vladislav V Kiselyov

series ordinal

3

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PubMed ID

21838706

31 July 2017

language of work or name

English

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publication date

1 December 2011

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31 July 2017

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31 July 2017

440

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31 July 2017

3

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31 July 2017

397-403

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Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

31 July 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Structural biology of insulin and IGF1 receptors: implications for drug design

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20110550

Structure and function of the type 1 insulin-like growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Structure of the human insulin receptor gene and characterization of its promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Alternative splicing of human insulin receptor messenger RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

The rat insulin receptor: primary structure and conservation of tissue-specific alternative messenger RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Insulin receptor exon 11+/- isoform mRNA in spontaneously hypertensive and adrenocorticotropin-hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Ligand-binding properties of the two isoforms of the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Insulin and its receptor: structure, function and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Structure of the insulin receptor ectodomain reveals a folded-over conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Structural basis of allosteric ligand-receptor interactions in the insulin/relaxin peptide family: implications for other receptor tyrosine kinases and G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

Molecular mechanisms of differential intracellular signaling from the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110550

21 January 2018

Identifiers

DOI

10.1042/BJ20110550

1 reference

31 July 2017

1 reference

PubMed ID

21838706