Molecular mechanisms of differential intracellular signaling from the insulin receptor (Q37403947)

20 August 2017

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title

Molecular mechanisms of differential intracellular signaling from the insulin receptor (English)

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20 August 2017

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Pierre De Meyts

2

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author name string

Maja Jensen

series ordinal

1

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20 August 2017

1 January 2009

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20 August 2017

Vitamins and Hormones

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20 August 2017

80

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20 August 2017

51-75

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Structure and function of the type 1 insulin-like growth factor receptor.

20 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Identification of Ser-1275 and Ser-1309 as autophosphorylation sites of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Endosomes, receptor tyrosine kinase internalization and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Intracellular signal transduction: The role of endosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The role of insulin dissociation from its endosomal receptor in insulin degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Annexin II is a novel player in insulin signal transduction. Possible association between annexin II phosphorylation and insulin receptor internalization.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Cis-autophosphorylation of juxtamembrane tyrosines in the insulin receptor kinase domain

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Increased in vivo phosphorylation of insulin receptor at serine 994 in the liver of obese insulin-resistant Zucker rats

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin and its receptor: structure, function and evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Structural biology of insulin and IGF1 receptors: implications for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Characterization of a second ligand binding site of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Receptor tyrosine kinases: mechanisms of activation and signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Caveolin; different roles for insulin signal?

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Alanine scanning mutagenesis of insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Functional reconstitution of insulin receptor binding site from non-binding receptor fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin receptor structure and its implications for the IGF-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Identification of serines-1035/1037 in the kinase domain of the insulin receptor as protein kinase C alpha mediated phosphorylation sites

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Structure of the insulin receptor ectodomain reveals a folded-over conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Analog binding properties of insulin receptor mutants. Identification of amino acids interacting with the COOH terminus of the B-chain of the insulin molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Peptides identify the critical hotspots involved in the biological activation of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Receptor-binding region of insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

A novel insulin analog with unique properties: LysB3,GluB29 insulin induces prominent activation of insulin receptor substrate 2, but marginal phosphorylation of insulin receptor substrate 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Engineering epidermal growth factor for enhanced mitogenic potency

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin Signaling in Microdomains of the Plasma Membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Identification of Stat 5B as a substrate of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

A model for insulin binding to the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Protein kinase C and lipid-induced insulin resistance in skeletal muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Alternative splicing of human insulin receptor messenger RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Structure of the human insulin receptor gene and characterization of its promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Pool of ligand-bound platelet-derived growth factor beta-receptors remain activated and tyrosine phosphorylated after internalization

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Interaction of EGF receptor and grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The location and characterisation of the O-linked glycans of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

N-linked glycans of the human insulin receptor and their distribution over the crystal structure

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin receptor signaling through non‐tyrosine kinase pathways: Evidence from anti‐receptor antibodies and insulin receptor mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Isoform-specific insulin receptor signaling involves different plasma membrane domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Selective gene activation by spatial segregation of insulin receptor B signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Control of EGF receptor signaling by clathrin-mediated endocytosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Structural insights into ligand-induced activation of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Regulation of insulin receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

The structure of 2Zn pig insulin crystals at 1.5 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

Timing-dependent modulation of insulin mitogenic versus metabolic signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900603-1

7 January 2021

10.1016/S0083-6729(08)00603-1

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19251034