Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue. (Q34208123)

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20 February 2020

review article

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14 October 2020

20 July 2021

Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue (English)

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20 February 2020

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11 October 2019

complement system proteins

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14 October 2020

complement activation

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20 July 2021

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14 October 2020

3

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Boguslaw Machalinski

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Anna Machalinska

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Milosz P Kawa

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Journal of Immunology Research

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11 October 2019

27 November 2019

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cites work

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28 July 2018

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Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

28 July 2018

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Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

28 July 2018

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited

28 July 2018

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28 July 2018

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Genetic control of the alternative pathway of complement in humans and age-related macular degeneration

28 July 2018

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CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Variation near complement factor I is associated with risk of advanced AMD

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production

28 July 2018

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Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells

28 July 2018

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Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

28 July 2018

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Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications

28 July 2018

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Molecular genetics of AMD and current animal models

28 July 2018

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Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments

28 July 2018

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A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration

28 July 2018

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Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

28 July 2018

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28 July 2018

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Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.

28 July 2018

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Interleukin-1beta and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes

28 July 2018

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

28 July 2018

1 reference

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Complement: a novel factor in basal and ischemia-induced neurogenesis

28 July 2018

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28 July 2018

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A simplified severity scale for age-related macular degeneration: AREDS Report No. 18

28 July 2018

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Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles

28 July 2018

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

28 July 2018

1 reference

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The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences

28 July 2018

1 reference

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Complement factor H polymorphism in age-related macular degeneration

28 July 2018

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Complement factor H polymorphism and age-related macular degeneration

28 July 2018

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Complement factor H variant increases the risk of age-related macular degeneration

28 July 2018

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Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization

28 July 2018

1 reference

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Complement: a unique innate immune sensor for danger signals

28 July 2018

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Current concepts in the pathogenesis of age-related macular degeneration

28 July 2018

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Prevalence of age-related macular degeneration in the United States

28 July 2018

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Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection

28 July 2018

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

28 July 2018

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A role for local inflammation in the formation of drusen in the aging eye.

28 July 2018

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The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

28 July 2018

1 reference

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Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

28 July 2018

1 reference

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Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death

28 July 2018

1 reference

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Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

28 July 2018

1 reference

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The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.

28 July 2018

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Inflammatory signals induce neurotrophin expression in human microglial cells

28 July 2018

1 reference

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Sublytic complement attack induces cell cycle in oligodendrocytes.

28 July 2018

1 reference

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Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells

28 July 2018

1 reference

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Age-Related Macular Degeneration

28 July 2018

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Elevated plasma levels of C3a complement compound in the exudative form of age-related macular degeneration.

21 January 2018

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A potential role for immune complex pathogenesis in drusen formation

21 January 2018

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The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration

21 January 2018

1 reference

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Regulated secretion of complement factor H by RPE and its role in RPE migration

21 January 2018

1 reference

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Enhanced expression of the complement factor H mRNA in proliferating human RPE cells

21 January 2018

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Expression and modulation of RPE cell membrane complement regulatory proteins.

21 January 2018

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CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration

21 January 2018

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Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration

21 January 2018

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Evidence for association between multiple complement pathway genes and AMD.

21 January 2018

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Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes

21 January 2018

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Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization

21 January 2018

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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy

21 January 2018

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Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Role of ocular complement factor H in a murine model of choroidal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Functions of C5a receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

A novel role of complement in retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizone model

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F483960

Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168147

28 October 2018

1 reference

12 December 2020

Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration

1 reference

12 December 2020

The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study

1 reference

12 December 2020

Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation

1 reference

12 December 2020

Sublytic C5b-9-stimulated Schwann cell survival through PI 3-kinase-mediated phosphorylation of BAD

1 reference

12 December 2020

Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration

1 reference

12 December 2020

The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration

1 reference

12 December 2020

A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis

1 reference

12 December 2020

C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion

1 reference

12 December 2020

Complement factor H polymorphisms in Japanese population with age-related macular degeneration

1 reference

12 December 2020

Identifiers

DOI

10.1155/2014/483960

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25276841%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25276841%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25276841%20AND%20SRC:MED&resulttype=core&format=json