Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development (Q34480087)

2 August 2017

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development (English)

1 reference

2 August 2017

1 reference

Shunbin Xiong

1

1 reference

2 August 2017

Carolyn S Van Pelt

2

1 reference

2 August 2017

Ana C Elizondo-Fraire

3

1 reference

2 August 2017

Geng Liu

4

1 reference

2 August 2017

Guillermina Lozano

5

1 reference

2 August 2017

language of work or name

English

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publication date

21 February 2006

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

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2 August 2017

103

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2 August 2017

3226-3231

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2 August 2017

9

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Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

P53 and prognosis: new insights and further complexity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

The ubiquitin ligase COP1 is a critical negative regulator of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

MDM2 promotes ubiquitination and degradation of MDMX

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

MDM2--master regulator of the p53 tumor suppressor protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

New approaches to understanding p53 gene tumor mutation spectra

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

MdmX protects p53 from Mdm2-mediated degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

MDM2 interacts with MDMX through their RING finger domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Generalized lacZ expression with the ROSA26 Cre reporter strain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

MDM2 expression during mouse embryogenesis and the requirement of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Regulation of p53 stability by Mdm2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Mdm2 promotes the rapid degradation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

MDMX: a novel p53-binding protein with some functional properties of MDM2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

The organization and expression of the mdm2 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0508500103

Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0508500103

The mouse tissue plasminogen activator gene 5' flanking region directs appropriate expression in development and a seizure-enhanced response in the CNS.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413885

Comparative study of the p53-mdm2 and p53-MDMX interfaces

27 October 2018

1 reference

12 December 2020

The loss of mdm2 induces p53-mediated apoptosis

1 reference

12 December 2020

Hdmx stabilizes Mdm2 and p53

1 reference

12 December 2020

An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

1 reference

12 December 2020

Conditional allele of mdm2 which encodes a p53 inhibitor

1 reference

12 December 2020

mdmx is a negative regulator of p53 activity in vivo

1 reference

12 December 2020

Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets

1 reference

12 December 2020

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

12 December 2020

Tangential migration of neurons in the developing cerebral cortex

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0508500103

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference