PTP1B: from the sidelines to the front lines! (Q34209253)

31 July 2017

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title

PTP1B: from the sidelines to the front lines! (English)

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31 July 2017

Nicholas K Tonks

1

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PubMed ID

12829250

31 July 2017

language of work or name

English

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publication date

1 July 2003

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31 July 2017

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31 July 2017

546

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31 July 2017

1

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31 July 2017

140-148

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Structural and evolutionary relationships among protein tyrosine phosphatase domains

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Cloning of a cDNA for a major human protein-tyrosine-phosphatase

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Cloning and expression of a protein-tyrosine-phosphatase

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Insulin-inducible changes in the relative ratio of PTP1B splice variants.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

The Noncatalytic C-terminal Segment of the T Cell Protein Tyrosine Phosphatase Regulates Activity via an Intramolecular Mechanism

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Insulin stimulates tyrosine phosphorylation and inactivation of protein-tyrosine phosphatase 1B in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein tyrosine phosphatases: mechanisms of catalysis and regulation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Crystal structure of human protein tyrosine phosphatase 1B

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Regulation of PTP1B via glutathionylation of the active site cysteine 215

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein tyrosine phosphatase 1B negatively regulates integrin signaling

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein tyrosine phosphatase-1B in diabetes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

PTP1B regulates leptin signal transduction in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Acquisition of a specific and potent PTP1B inhibitor from a novel combinatorial library and screening procedure

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Protein kinases--the major drug targets of the twenty-first century?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2803%2900603-3

10.1016/S0014-5793(03)00603-3

7 January 2021

Identifiers

DOI

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31 July 2017

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PubMed ID

12829250