Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia (Q34213539)

31 July 2017

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia (English)

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31 July 2017

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lymphoblastic leukemia

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inferred from title

acute T cell leukemia

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Daniel Ribeiro

2

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André B Silveira

André B Silveira

9

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Leonor M Sarmento

Leonor M Sarmento

11

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Bruno A Cardoso

Bruno A Cardoso

10

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Jörg Kobarg

Jörg Kobarg

14

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João T. Barata

João T Barata

22

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María L Toribio

Maria L Toribio

13

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Jules P Meijerink

Jules P Meijerink

19

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Rob Pieters

16

Rob Pieters

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31 July 2017

Priscila P Zenatti

1

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31 July 2017

Wenqing Li

3

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31 July 2017

Linda Zuurbier

4

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31 July 2017

Milene C Silva

5

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31 July 2017

Maddalena Paganin

6

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31 July 2017

Julia Tritapoe

7

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31 July 2017

Julie A Hixon

8

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31 July 2017

Nádia Correia

12

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31 July 2017

Martin Horstmann

15

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31 July 2017

Silvia R Brandalise

17

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31 July 2017

Adolfo A Ferrando

18

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31 July 2017

Scott K Durum

20

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31 July 2017

J Andrés Yunes

21

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31 July 2017

language of work or name

English

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publication date

4 September 2011

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31 July 2017

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31 July 2017

43

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10

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932-939

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describes a project that uses

31 July 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/7424552

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ng.924

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cites work

Cell biology of IL-7, a key lymphotrophin

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The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance

21 January 2018

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

21 January 2018

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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

21 January 2018

1 reference

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

21 January 2018

1 reference

Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

21 January 2018

1 reference

Risk alleles for multiple sclerosis identified by a genomewide study

21 January 2018

1 reference

Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice

21 January 2018

1 reference

Haploinsufficiency identifies STAT5 as a modifier of IL-7-induced lymphomas

21 January 2018

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Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development.

21 January 2018

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Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

21 January 2018

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CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia

21 January 2018

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

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Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

21 January 2018

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Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

21 January 2018

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Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling

21 January 2018

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Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

21 January 2018

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

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Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.

21 January 2018

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Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

21 January 2018

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Activating alleles of JAK3 in acute megakaryoblastic leukemia

21 January 2018

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Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

21 January 2018

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

21 January 2018

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

21 January 2018

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PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

21 January 2018

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High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

21 January 2018

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

21 January 2018

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

21 January 2018

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NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

21 January 2018

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Characterization of an interleukin-7-dependent thymic cell line derived from a p53(-/-) mouse

21 January 2018

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Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains

21 January 2018

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Self-association of the transmembrane domain of RET underlies oncogenic activation by MEN2A mutations

21 January 2018

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Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface

21 January 2018

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Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

21 January 2018

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Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

21 January 2018

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Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

21 January 2018

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Tryptophan supports interaction of transmembrane helices

21 January 2018

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The GxxxG motif: a framework for transmembrane helix-helix association

21 January 2018

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CREBBP mutations in relapsed acute lymphoblastic leukaemia

21 January 2018

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Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia

21 January 2018

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Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

21 January 2018

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PHF6 mutations in T-cell acute lymphoblastic leukemia

21 January 2018

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Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.

21 January 2018

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Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper

21 January 2018

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Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia.

21 January 2018

1 reference

12 December 2020

Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).

1 reference

12 December 2020

Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia

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12 December 2020

Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.

1 reference

12 December 2020

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

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12 December 2020

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours

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12 December 2020

A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency

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12 December 2020

Identifiers

DOI

10.1038/NG.924

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31 July 2017

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